Immunity and inflammation in neurodegenerative diseases

Immune reactions inside the central nervous system are finely regulated, thanks to the presence of several checkpoints that have the fundamental purpose to preserve this fragile tissue form harmful events. The current knowledge on the role of neuroinflammation and neuro-immune interactions in the fi...

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Bibliographic Details
Published in:American journal of neurodegenerative disease 2013, Vol.2 (2), p.89-107
Main Authors: Cappellano, Giuseppe, Carecchio, Miryam, Fleetwood, Thomas, Magistrelli, Luca, Cantello, Roberto, Dianzani, Umberto, Comi, Cristoforo
Format: Article
Language:English
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Review
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Summary:Immune reactions inside the central nervous system are finely regulated, thanks to the presence of several checkpoints that have the fundamental purpose to preserve this fragile tissue form harmful events. The current knowledge on the role of neuroinflammation and neuro-immune interactions in the fields of multiple sclerosis, Alzheimer's disease and Parkinson's disease is reviewed. Moreover, a focus on the potential role of both active and passive immunotherapy is provided. Finally, we propose a common perspective, which implies that, under pathological conditions, inflammation may exert both detrimental and protective functions, depending on local factors and the timing of immune activation and shutting-off systems.
ISSN:2165-591X
2165-591X