Proton magnetic resonance spectroscopy of human cervical spondylosis at 3T

Study design: A single-center magnetic resonance imaging and spectroscopic study involving 21 patients with advanced cervical spondylosis and 11 healthy controls. Objective: We assessed the utility of magnetic resonance spectroscopy (MRS) to quantify biochemical changes within the spinal cord and se...

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Bibliographic Details
Published in:Spinal cord 2013-07, Vol.51 (7), p.558-563
Main Authors: Salamon, N, Ellingson, B M, Nagarajan, R, Gebara, N, Thomas, A, Holly, L T
Format: Article
Language:English
Subjects:
692/53
692/699/375/1824
692/700/1421/1628
Anatomy
Aspartic Acid - analogs & derivatives
Aspartic Acid - analysis
Biomarkers - analysis
Biomedical and Life Sciences
Biomedicine
Choline - analysis
Creatine - analysis
Human Physiology
Humans
Magnetic Resonance Imaging - methods
Magnetic Resonance Spectroscopy - methods
Middle Aged
Neurochemistry
Neuropsychology
Neurosciences
original-article
Protons
Reproducibility of Results
Sensitivity and Specificity
Spondylosis - diagnosis
Spondylosis - metabolism
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Summary:Study design: A single-center magnetic resonance imaging and spectroscopic study involving 21 patients with advanced cervical spondylosis and 11 healthy controls. Objective: We assessed the utility of magnetic resonance spectroscopy (MRS) to quantify biochemical changes within the spinal cord and serve as a potential biomarker in patients with cervical spondylosis with or without T2 hyperintensity within the cord. Setting: Los Angeles, California, USA. Methods: Twenty-one patients with cervical spondylosis and eleven healthy controls were evaluated. Single-voxel MRS was performed in the cervical cord. Morphometry of the spinal canal space was measured. N -Acetyl aspartylglutamic acid (NAA), choline (Cho), myo-inositol (Myo-I), glutamine–glutamate complex (Glx) and lactate metabolite concentration ratios with respect to total creatine (Cr) were quantified using an LC model algorithm and compared between healthy controls and spondylosis patients. Correlation of MRS metabolites with modified Japanese Orthopaedic Association (mJOA) score was also performed. Results: The spinal canal space was significantly different between patients and controls (analysis of variance (ANOVA), P
ISSN:1362-4393
1476-5624
DOI:10.1038/sc.2013.31