Temperature-Sensitive Transitions below LCST in Amphiphilic Dendritic Assemblies: Host–Guest Implications

Oligo­(ethylene glycol)-decorated supramolecular assemblies have been of great interest due to their charge-neutral character and thus their propensity to avoid nonspecific interactions. These systems are known to exhibit a macroscopic temperature-sensitive transition, where the assembly phase-separ...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2013-06, Vol.135 (24), p.8947-8954
Main Authors: Fuller, Jack M, Raghupathi, Krishna R, Ramireddy, Rajasekhar R, Subrahmanyam, Ayyagari V, Yesilyurt, Volkan, Thayumanavan, S
Format: Article
Language:English
Subjects:
Delayed-Action Preparations - chemistry
Ethylene Glycol - chemistry
Phase Transition
Transition Temperature
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Summary:Oligo­(ethylene glycol)-decorated supramolecular assemblies have been of great interest due to their charge-neutral character and thus their propensity to avoid nonspecific interactions. These systems are known to exhibit a macroscopic temperature-sensitive transition, where the assembly phase-separates from the aqueous phase at higher temperatures. While this so-called lower critical solution temperature (LCST) behavior has been well-studied, there have been no studies on the fate of these supramolecular assemblies below this transition temperature. The work here brings to light the presence of a second, sub-LCST transition, observed well below the LCST of oligo­(ethylene glycol) (OEG)-based dendrons, where the host–guest properties of the assembly are significantly altered. This sub-LCST transition is accompanied by changes in the guest encapsulation stability and dynamics of host exchange.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja402019c