Immunomodulatory Effect of Mangiferin in Experimental Animals with Benzo(a)Pyrene-induced Lung Carcinogenesis

The immunomodulatory activity of mangiferin was studied in various groups of animals. For this study, adult Swiss albino male mice were treated with benzo(a)pyrene, abbreviated as B(a)P, at 50 mg/kg body weight orally twice a week for 4 weeks; and mangiferin was also given orally (pre- and post-init...

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Bibliographic Details
Published in:International journal of biomedical science 2013-06, Vol.9 (2), p.68-74
Main Authors: Rajendran, Peramaiyan, Jayakumar, Thangavel, Nishigaki, Ikuo, Ekambaram, Ganapathy, Nishigaki, Yutaka, Vetriselvi, Jayabal, Sakthisekaran, Dhanapal
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Language:English
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Summary:The immunomodulatory activity of mangiferin was studied in various groups of animals. For this study, adult Swiss albino male mice were treated with benzo(a)pyrene, abbreviated as B(a)P, at 50 mg/kg body weight orally twice a week for 4 weeks; and mangiferin was also given orally (pre- and post-initiation of carcinoma) at 100 mg/kg body weight. Immunocompetence and immune complexes as measured by phagocyte index, avidity index, and soluble immune complex (SIC) levels (p
ISSN:1550-9702
1555-2810
DOI:10.59566/IJBS.2013.9068