Blastic Plasmacytoid Dendritic Cell Neoplasm: A Report of 2 Cases

Blastic plasmacytoid dendritic cell neoplasm is a recently classified aggressive hematodermic neoplasm derived from plasmacytoid dendritic cells. We describe two cases of this neoplasm, one a 15 year old child and other a 65 year male. The diagnosis was made by evaluating the detailed clinical histo...

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Bibliographic Details
Published in:Indian journal of hematology & blood transfusion 2013-09, Vol.29 (3), p.171-172
Main Authors: Arora, Raman, Sachdev, Ritesh, Bind, Tribhuwan, Khan, Md Ateek
Format: Article
Language:English
Subjects:
Blood Transfusion Medicine
Case Report
Cellular biology
Hematology
Human Genetics
Leukemia
Medical diagnosis
Medicine
Medicine & Public Health
Oncology
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Description
Summary:Blastic plasmacytoid dendritic cell neoplasm is a recently classified aggressive hematodermic neoplasm derived from plasmacytoid dendritic cells. We describe two cases of this neoplasm, one a 15 year old child and other a 65 year male. The diagnosis was made by evaluating the detailed clinical history, morphology and flow cytometric findings. The diagnosis is rendered difficult owing to common morphological and flow cytometric overlaps. The neoplasms were characterized by skin and soft tissue involvement and strong CD4/CD56 positivity. These neoplasms are highly aggressive and have many diagnostic overlaps. Strong suspicion and detection will help in early therapeutic interventions.
ISSN:0971-4502
0974-0449
0974-0449
0971-4502
DOI:10.1007/s12288-012-0171-x