Age-related changes in the corpus callosum in early-onset bipolar disorder assessed using volumetric and cross-sectional measurements

Corpus callosum (CC) area abnormalities have been reported in magnetic resonance imaging (MRI) studies of adults and youths with bipolar disorder (BPD), suggesting interhemispheric communication may be abnormal in BPD and may be present early in the course of illness and affect normal neuromaturatio...

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Bibliographic Details
Published in:Brain imaging and behavior 2010-12, Vol.4 (3-4), p.220-231
Main Authors: Lopez-Larson, Melissa, Breeze, Janis L, Kennedy, David N, Hodge, Steven M, Tang, Lena, Moore, Constance, Giuliano, Anthony J, Makris, Nikos, Caviness, Verne S, Frazier, Jean A
Format: Article
Language:English
Subjects:
Adolescent
Age
Aging - physiology
Anatomy, Cross-Sectional
Biomedical and Life Sciences
Biomedicine
Bipolar disorder
Bipolar Disorder - pathology
Bipolar Disorder - psychology
Child
Corpus callosum
Corpus Callosum - growth & development
Corpus Callosum - pathology
Data Interpretation, Statistical
Diagnostic and Statistical Manual of Mental Disorders
Female
Functional Laterality - physiology
Humans
Image Processing, Computer-Assisted
Linear Models
Magnetic Resonance Imaging
Male
Medical research
MRI
Myelin Sheath - pathology
Neuroimaging
Neuropsychology
Neuroradiology
Neurosciences
Original Research
Psychiatry
Youths
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Summary:Corpus callosum (CC) area abnormalities have been reported in magnetic resonance imaging (MRI) studies of adults and youths with bipolar disorder (BPD), suggesting interhemispheric communication may be abnormal in BPD and may be present early in the course of illness and affect normal neuromaturation of this structure throughout the lifecycle. Neuroimaging scans from 44 youths with DSM-IV BPD and 22 healthy controls (HC) were analyzed using cross-sectional area measurements and a novel method of volumetric parcellation. Univariate analyses of variance were conducted on CC subregions using both volume and traditional area measurements. Youths with BPD had smaller middle and posterior callosal regions, and reduced typical age-related increases in CC size. The cross-sectional area and novel volumetric methodologies resulted in similar findings. Future longitudinal assessments of CC development would track the evolution of callosal abnormalities in youths with BPD and allow exploration of the functional significance of these findings.
ISSN:1931-7557
1931-7565
DOI:10.1007/s11682-010-9101-4