CD117 expression in operable oesophageal squamous cell carcinomas predicts worse clinical outcome

Aims To investigate the aberrant expression of CD117 in oesophageal squamous cell carcinoma (SCC) and its prognostic significance. Methods and results Immunohistochemical staining for CD117 was performed on tissue microarray and routine tissue sections from 157 oesophageal SCC patients and 10 normal...

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Bibliographic Details
Published in:Histopathology 2013-06, Vol.62 (7), p.1028-1037
Main Authors: Fan, Huijie, Yuan, Yuan, Wang, Junsheng, Zhou, Fuyou, Zhang, Mingzhi, Giercksky, Karl-Erik, Nesland, Jahn M, Suo, Zhenhe
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers, Tumor - metabolism
cancer stem cell
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - secondary
CD117
China - epidemiology
Combined Modality Therapy
Esophageal Neoplasms - metabolism
Esophageal Neoplasms - mortality
Esophageal Neoplasms - pathology
Esophagectomy
Female
Humans
immunohistochemistry
Lymph Nodes - pathology
Lymphatic Metastasis
Male
Middle Aged
oesophageal squamous cell carcinoma
Original
Prognosis
Proto-Oncogene Proteins c-kit - metabolism
stem cell factor
Survival Rate
Tissue Array Analysis
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Summary:Aims To investigate the aberrant expression of CD117 in oesophageal squamous cell carcinoma (SCC) and its prognostic significance. Methods and results Immunohistochemical staining for CD117 was performed on tissue microarray and routine tissue sections from 157 oesophageal SCC patients and 10 normal oesophageal epithelia adjacent to tumour. The positive rate of CD117 expression was 29.9% in oesophageal SCC tissues, whereas no CD117 expression was detected in the 10 normal oesophageal epithelia. CD117 expression was significantly associated with T stage (P 
ISSN:0309-0167
1365-2559
DOI:10.1111/his.12111