Evaluation of Nonradiative Clinical Imaging Techniques for the Longitudinal Assessment of Tumour Growth in Murine CT26 Colon Carcinoma

Background and Objectives. To determine the most appropriate technique for tumour followup in experimental therapeutics, we compared ultrasound (US) and magnetic resonance imaging (MRI) to characterize ectopic and orthotopic colon carcinoma models. Methods. CT26 tumours were implanted subcutaneously...

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Bibliographic Details
Published in:International Journal of Molecular Imaging 2013-01, Vol.2013 (2013), p.129-141
Main Authors: Seguin, Johanne, Doan, Bich-Thuy, Latorre Ossa, Heldmuth, Jugé, Lauriane, Gennisson, Jean-Luc, Tanter, Mickaël, Scherman, Daniel, Chabot, Guy G., Mignet, Nathalie
Format: Article
Language:English
Subjects:
Abdomen
Analysis
Animals
Colon
Colon cancer
Colorectal cancer
Comparative analysis
Development and progression
Diagnostic imaging
Evaluation
Medical imaging
Mortality
Tumors
Ultrasonic imaging
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Summary:Background and Objectives. To determine the most appropriate technique for tumour followup in experimental therapeutics, we compared ultrasound (US) and magnetic resonance imaging (MRI) to characterize ectopic and orthotopic colon carcinoma models. Methods. CT26 tumours were implanted subcutaneously (s.c.) in Balb/c mice for the ectopic model or into the caecum for the orthotopic model. Tumours were evaluated by histology, spectrofluorescence, MRI, and US. Results. Histology of CT26 tumour showed homogeneously dispersed cancer cells and blood vessels. The visualization of the vascular network using labelled albumin showed that CT26 tumours were highly vascularized and disorganized. MRI allowed high-resolution and accurate 3D tumour measurements and provided additional anatomical and functional information. Noninvasive US imaging allowed good delineation of tumours despite an hypoechogenic signal. Monitoring of tumour growth with US could be accomplished as early as 5 days after implantation with a shorter acquisition time (
ISSN:2090-1712
2090-1720
DOI:10.1155/2013/983534