Evaluation of Nonradiative Clinical Imaging Techniques for the Longitudinal Assessment of Tumour Growth in Murine CT26 Colon Carcinoma

Background and Objectives. To determine the most appropriate technique for tumour followup in experimental therapeutics, we compared ultrasound (US) and magnetic resonance imaging (MRI) to characterize ectopic and orthotopic colon carcinoma models. Methods. CT26 tumours were implanted subcutaneously...

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Published in:International Journal of Molecular Imaging 2013-01, Vol.2013 (2013), p.129-141
Main Authors: Seguin, Johanne, Doan, Bich-Thuy, Latorre Ossa, Heldmuth, Jugé, Lauriane, Gennisson, Jean-Luc, Tanter, Mickaël, Scherman, Daniel, Chabot, Guy G., Mignet, Nathalie
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Language:English
Subjects:
Abdomen
Analysis
Animals
Colon
Colon cancer
Colorectal cancer
Comparative analysis
Development and progression
Diagnostic imaging
Evaluation
Medical imaging
Mortality
Tumors
Ultrasonic imaging
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container_issue 2013
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container_title International Journal of Molecular Imaging
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creator Seguin, Johanne
Doan, Bich-Thuy
Latorre Ossa, Heldmuth
Jugé, Lauriane
Gennisson, Jean-Luc
Tanter, Mickaël
Scherman, Daniel
Chabot, Guy G.
Mignet, Nathalie
description Background and Objectives. To determine the most appropriate technique for tumour followup in experimental therapeutics, we compared ultrasound (US) and magnetic resonance imaging (MRI) to characterize ectopic and orthotopic colon carcinoma models. Methods. CT26 tumours were implanted subcutaneously (s.c.) in Balb/c mice for the ectopic model or into the caecum for the orthotopic model. Tumours were evaluated by histology, spectrofluorescence, MRI, and US. Results. Histology of CT26 tumour showed homogeneously dispersed cancer cells and blood vessels. The visualization of the vascular network using labelled albumin showed that CT26 tumours were highly vascularized and disorganized. MRI allowed high-resolution and accurate 3D tumour measurements and provided additional anatomical and functional information. Noninvasive US imaging allowed good delineation of tumours despite an hypoechogenic signal. Monitoring of tumour growth with US could be accomplished as early as 5 days after implantation with a shorter acquisition time (
doi_str_mv 10.1155/2013/983534
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To determine the most appropriate technique for tumour followup in experimental therapeutics, we compared ultrasound (US) and magnetic resonance imaging (MRI) to characterize ectopic and orthotopic colon carcinoma models. Methods. CT26 tumours were implanted subcutaneously (s.c.) in Balb/c mice for the ectopic model or into the caecum for the orthotopic model. Tumours were evaluated by histology, spectrofluorescence, MRI, and US. Results. Histology of CT26 tumour showed homogeneously dispersed cancer cells and blood vessels. The visualization of the vascular network using labelled albumin showed that CT26 tumours were highly vascularized and disorganized. MRI allowed high-resolution and accurate 3D tumour measurements and provided additional anatomical and functional information. Noninvasive US imaging allowed good delineation of tumours despite an hypoechogenic signal. Monitoring of tumour growth with US could be accomplished as early as 5 days after implantation with a shorter acquisition time (&lt;5 min) compared to MRI. Conclusion. MRI and US afforded excellent noninvasive imaging techniques to accurately follow tumour growth of ectopic and orthotopic CT26 tumours. These two techniques can be appropriately used for tumour treatment followup, with a preference for US imaging, due to its short acquisition time and simplicity of use.</description><identifier>ISSN: 2090-1712</identifier><identifier>EISSN: 2090-1720</identifier><identifier>DOI: 10.1155/2013/983534</identifier><identifier>PMID: 23936648</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Limiteds</publisher><subject>Abdomen ; Analysis ; Animals ; Colon ; Colon cancer ; Colorectal cancer ; Comparative analysis ; Development and progression ; Diagnostic imaging ; Evaluation ; Medical imaging ; Mortality ; Tumors ; Ultrasonic imaging</subject><ispartof>International Journal of Molecular Imaging, 2013-01, Vol.2013 (2013), p.129-141</ispartof><rights>Copyright © 2013 Johanne Seguin et al.</rights><rights>COPYRIGHT 2013 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2013 Johanne Seguin et al. Johanne Seguin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Johanne Seguin et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a4474-1aafef15c48fd5c2187afcc0583b9a6eb24a31172817132ca67337e08714f2433</citedby><cites>FETCH-LOGICAL-a4474-1aafef15c48fd5c2187afcc0583b9a6eb24a31172817132ca67337e08714f2433</cites><orcidid>0000-0001-5689-7046</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1428036049/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1428036049?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23936648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Watabe, Hiroshi</contributor><creatorcontrib>Seguin, Johanne</creatorcontrib><creatorcontrib>Doan, Bich-Thuy</creatorcontrib><creatorcontrib>Latorre Ossa, Heldmuth</creatorcontrib><creatorcontrib>Jugé, Lauriane</creatorcontrib><creatorcontrib>Gennisson, Jean-Luc</creatorcontrib><creatorcontrib>Tanter, Mickaël</creatorcontrib><creatorcontrib>Scherman, Daniel</creatorcontrib><creatorcontrib>Chabot, Guy G.</creatorcontrib><creatorcontrib>Mignet, Nathalie</creatorcontrib><title>Evaluation of Nonradiative Clinical Imaging Techniques for the Longitudinal Assessment of Tumour Growth in Murine CT26 Colon Carcinoma</title><title>International Journal of Molecular Imaging</title><addtitle>Int J Mol Imaging</addtitle><description>Background and Objectives. To determine the most appropriate technique for tumour followup in experimental therapeutics, we compared ultrasound (US) and magnetic resonance imaging (MRI) to characterize ectopic and orthotopic colon carcinoma models. Methods. CT26 tumours were implanted subcutaneously (s.c.) in Balb/c mice for the ectopic model or into the caecum for the orthotopic model. Tumours were evaluated by histology, spectrofluorescence, MRI, and US. Results. Histology of CT26 tumour showed homogeneously dispersed cancer cells and blood vessels. The visualization of the vascular network using labelled albumin showed that CT26 tumours were highly vascularized and disorganized. MRI allowed high-resolution and accurate 3D tumour measurements and provided additional anatomical and functional information. Noninvasive US imaging allowed good delineation of tumours despite an hypoechogenic signal. 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subjects Abdomen
Analysis
Animals
Colon
Colon cancer
Colorectal cancer
Comparative analysis
Development and progression
Diagnostic imaging
Evaluation
Medical imaging
Mortality
Tumors
Ultrasonic imaging
title Evaluation of Nonradiative Clinical Imaging Techniques for the Longitudinal Assessment of Tumour Growth in Murine CT26 Colon Carcinoma
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