Diastolic Field Stimulation: the Role of Shock Duration in Epicardial Activation and Propagation

Detailed knowledge of tissue response to both systolic and diastolic shock is critical for understanding defibrillation. Diastolic field stimulation has been much less studied than systolic stimulation, particularly regarding transient virtual anodes. Here we investigated high-voltage-induced polari...

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Bibliographic Details
Published in:Biophysical journal 2013-07, Vol.105 (2), p.523-532
Main Authors: Woods, Marcella C., Uzelac, Ilija, Holcomb, Mark R., Wikswo, John P., Sidorov, Veniamin Y.
Format: Article
Language:English
Subjects:
Animals
Biophysics
blood pressure
Cardiovascular system
Defibrillators
Diastole
Electric Countershock
electricity
electrodes
Epicardial Mapping
Flow velocity
heart
Heart rate
In Vitro Techniques
Models, Cardiovascular
Myocardial Perfusion Imaging
Pericardium - physiology
Rabbits
stunning methods
Systems Biophysics
Time Factors
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Summary:Detailed knowledge of tissue response to both systolic and diastolic shock is critical for understanding defibrillation. Diastolic field stimulation has been much less studied than systolic stimulation, particularly regarding transient virtual anodes. Here we investigated high-voltage-induced polarization and activation patterns in response to strong diastolic shocks of various durations and of both polarities, and tested the hypothesis that the activation versus shock duration curve contains a local minimum for moderate shock durations, and it grows for short and long durations. We found that 0.1–0.2-ms shocks produced slow and heterogeneous activation. During 0.8–1 ms shocks, the activation was very fast and homogeneous. Further shock extension to 8 ms delayed activation from 1.55 ± 0.27 ms and 1.63 ± 0.21 ms at 0.8 ms shock to 2.32 ± 0.41 ms and 2.37 ± 0.3 ms (N = 7) for normal and opposite polarities, respectively. The traces from hyperpolarized regions during 3–8 ms shocks exhibited four different phases: beginning negative polarization, fast depolarization, slow depolarization, and after-shock increase in upstroke velocity. Thus, the shocks of >3 ms in duration created strong hyperpolarization associated with significant delay (P < 0.05) in activation compared with moderate shocks of 0.8 and 1 ms. This effect appears as a dip in the activation-versus-shock-duration curve.
ISSN:0006-3495
1542-0086
DOI:10.1016/j.bpj.2013.06.009