Parathyroid hormone acutely increases polyphosphoinositides of the rabbit kidney cortex by a cycloheximide-sensitive process

Parathyroid hormone(PTH) rapidly increases the concentrations of diphosphoinositide and triphosphoinositide in rabbit kidney cortex. Cycloheximide pretreatment abolishes these effects of PTH. These findings are similar to those reported for adrenocorticotropin and cyclic AMP action in the adrenal co...

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Bibliographic Details
Published in:The Journal of clinical investigation 1980-06, Vol.65 (6), p.1523-1526
Main Authors: Farese, R V, Bidot-López, P, Sabir, A, Smith, J S, Schinbeckler, B, Larson, R
Format: Article
Language:English
Subjects:
Animals
Cycloheximide - pharmacology
Kidney Cortex - metabolism
Male
Parathyroid Hormone - antagonists & inhibitors
Parathyroid Hormone - pharmacology
Phosphatidylinositols - metabolism
Rabbits
Stimulation, Chemical
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Summary:Parathyroid hormone(PTH) rapidly increases the concentrations of diphosphoinositide and triphosphoinositide in rabbit kidney cortex. Cycloheximide pretreatment abolishes these effects of PTH. These findings are similar to those reported for adrenocorticotropin and cyclic AMP action in the adrenal cortex, and suggest a common mechanism. Cycloheximide-sensitive effects of PTH, e.g., phosphaturia, may require polyphosphoinositides and/or other phospholipids.
ISSN:0021-9738
DOI:10.1172/JCI109818