Painful nerve injury decreases sarco-endoplasmic reticulum Ca2+ -ATPase activity in axotomized sensory neurons

Highlights ► SERCA regulates [Ca2+ ]c at rest and during recovery from activity. ► Repeated neuronal activation slows SERCA function. ► Injury reduces SERCA function in small sensory neurons.

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Bibliographic Details
Published in:Neuroscience 2013-02, Vol.231, p.247-257
Main Authors: Duncan, C, Mueller, S, Simon, E, Renger, J.J, Uebele, V.N, Hogan, Q.H, Wu, H.-e
Format: Article
Language:English
Subjects:
Animals
Axotomy
Biological and medical sciences
Ca2+ homeostasis
Calcium - metabolism
Calcium Signaling - drug effects
Calcium Signaling - physiology
Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction
endoplasmic reticulum
Endoplasmic Reticulum - drug effects
Endoplasmic Reticulum - metabolism
Enzyme Inhibitors - pharmacology
Male
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
neuropathic pain
Pain - metabolism
Rats
Rats, Sprague-Dawley
sarco-endoplasmic reticulum Ca2+-ATPase
Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism
sensory neuron
Sensory Receptor Cells - drug effects
Sensory Receptor Cells - metabolism
Spinal Nerves - drug effects
Spinal Nerves - injuries
Spinal Nerves - metabolism
Thapsigargin - pharmacology
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Description
Summary:Highlights ► SERCA regulates [Ca2+ ]c at rest and during recovery from activity. ► Repeated neuronal activation slows SERCA function. ► Injury reduces SERCA function in small sensory neurons.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.11.055