Alterations in the Achilles tendon after inflammation in surrounding tissue

To analyze the characteristics of the Achilles tendon of rats after induction of localized inflammation in the rat paw. IN OUR STUDY THREE GROUPS WERE USED: inflamed group with carrageenan in rat paw (G1); saline group (G2) and control group (G3). After 4 hours the animals were euthanized and the Ac...

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Published in:Acta ortopedica brasileira 2012, Vol.20 (5), p.266-269
Main Authors: Vieira, Cristiano Pedrozo, Guerra, Flávia da Ré, de Oliveira, Letícia Prado, de Almeida, Marcos Dos Santos, Pimentel, Edson Rosa
Format: Article
Language:English
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Summary:To analyze the characteristics of the Achilles tendon of rats after induction of localized inflammation in the rat paw. IN OUR STUDY THREE GROUPS WERE USED: inflamed group with carrageenan in rat paw (G1); saline group (G2) and control group (G3). After 4 hours the animals were euthanized and the Achilles tendon removed. No significant differences were observed in the analysis of non-collagenous proteins, glycosaminoglycans and hydroxyproline in the groups but a tendency of reduction was verified in G1. As regards the organization of collagen molecules, no differences were observed between groups. With respect to MMPs activity, a stronger presence of the active isoform of MMP-2 in G1 was observed, suggesting that the remodeling was occurring. Thus, we conclude that the inflammatory process in rat paw may affect the remodeling of tendons located near the inflamed site. Level of Evidence I, Prognostic Studies - Investigating the Effect of a Patient Characteristic on the Outcome of Disease.
ISSN:1413-7852
1809-4406
DOI:10.1590/S1413-78522012000500004