The association of serum prolidase activity with developmental dysplasia of the hip

The purpose of this study was to evaluate serum prolidase activity in patients with developmental dysplasia of the hip (DDH). Prolidase enzyme activity was measured spectrophotometrically to pointing out the collagen metabolism. The prolidase activity in patients with DDH was significantly higher th...

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Bibliographic Details
Published in:Rheumatology international 2013-08, Vol.33 (8), p.1939-1942
Main Authors: Soran, N., Altindag, O., Aksoy, N., Çakır, H., Taşkın, A., Soran, M., Işıkan, E.
Format: Article
Language:English
Subjects:
Adolescent
Child
Collagen - metabolism
Dipeptidases - metabolism
Disease Progression
Female
Hip Dislocation, Congenital - enzymology
Humans
Male
Medicine
Medicine & Public Health
Original
Original Article
Rheumatology
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Summary:The purpose of this study was to evaluate serum prolidase activity in patients with developmental dysplasia of the hip (DDH). Prolidase enzyme activity was measured spectrophotometrically to pointing out the collagen metabolism. The prolidase activity in patients with DDH was significantly higher than that in the control group ( p  = 0.002). Furthermore, there was positive correlation between prolidase activity and dysplasia level. Increased serum prolidase activity may have played a role in the presence of DDH. We therefore hypothesized that the increased prolidase activity related to collagen turnover may be associated with etiopathogenesis and/or the progression of the disease.
ISSN:0172-8172
1437-160X
DOI:10.1007/s00296-013-2672-9