Bronchodilatory effect of ethanolic extract of the leaves of Nyctanthes arbortristis

Background: Nyctanthes arbortristis has been used in traditional medicine for the treatment of asthma and cough. Aim: In this study, bronchodilatory effect of ethanolic extract of the N. arbortristis was investigated under in vitro conditions. The concentration-response curve of the tracheal smooth...

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Bibliographic Details
Published in:Pharmacognosy research 2013-07, Vol.5 (3), p.169-172
Main Authors: Sopi, Ramadan, Hayat Khan, Muhammad
Format: Article
Language:English
Subjects:
Asthma
Drug therapy
Experiments
Histamine
Laboratory animals
Medicine, Botanic
Medicine, Herbal
Original
Smooth muscle
Studies
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Summary:Background: Nyctanthes arbortristis has been used in traditional medicine for the treatment of asthma and cough. Aim: In this study, bronchodilatory effect of ethanolic extract of the N. arbortristis was investigated under in vitro conditions. The concentration-response curve of the tracheal smooth muscle (TSM) to histamine was recorded in presence or absence of ethanolic extract and Nω-nitro-l-arginine methyl ester (L-NAME). Dose-response effect of ethanolic extract on pre-constricted tissues was investigated. The ethanolic extract inhibited the histamine-induced maximum contractile responses of TSM ( P < 0.001). Ethanolic extract also cause dose-dependent relaxation of TSM. These effects were reversed by L-NAME. Phytochemical analysis showed the presence of typical plant constituents. These results suggest the possible use of extract of the leaves of N. arbortristis as a bronchodilator in therapeutic treatment of asthma.
ISSN:0974-8490
0976-4836
0974-8490
DOI:10.4103/0974-8490.112422