Double-Effector Nanoparticles: A Synergistic Approach to Apoptotic Hyperthermia

Highly efficient apoptotic hyperthermia is achieved using a double‐effector nanoparticle that can generate reactive oxygen species (ROS) and heat. ROS render cancer cells more susceptible to subsequent heat treatment, which remarkably increases the degree of apoptotic cell death. Xenograft tumors (1...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2012-12, Vol.51 (50), p.12482-12485
Main Authors: Yoo, Dongwon, Jeong, Heeyeong, Preihs, Christian, Choi, Jin-sil, Shin, Tae-Hyun, Sessler, Jonathan L., Cheon, Jinwoo
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - therapeutic use
Antineoplastic Agents - toxicity
apoptosis
Apoptosis - drug effects
Cell Line, Tumor
gadolinium texaphyrin
Humans
hyperthermia
Hyperthermia, Induced
Magnetic Fields
magnetic nanoparticles
Metal Nanoparticles - chemistry
Metal Nanoparticles - therapeutic use
Metal Nanoparticles - toxicity
Metalloporphyrins - chemistry
Metalloporphyrins - therapeutic use
Metalloporphyrins - toxicity
Mice
Neoplasms - drug therapy
reactive oxygen species
Reactive Oxygen Species - metabolism
Temperature
Transplantation, Heterologous
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Summary:Highly efficient apoptotic hyperthermia is achieved using a double‐effector nanoparticle that can generate reactive oxygen species (ROS) and heat. ROS render cancer cells more susceptible to subsequent heat treatment, which remarkably increases the degree of apoptotic cell death. Xenograft tumors (100 mm3) in mice are completely eliminated within 8 days after a single mild magnetic hyperthermia treatment at 43 °C for 30 min.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201206400