The tyrosine phosphatase STEP constrains amygdala-dependent memory formation and neuroplasticity

Highlights ► The protein phosphatase STEP regulates signaling proteins involved in neuroplasticity. ► The effect of STEP on neuroplasticity was examined in genetically modified mice. ► STEP deletion facilitates fear learning in mice. ► STEP deletion increases ERK activity in the basolateral amygdala...

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Bibliographic Details
Published in:Neuroscience 2012-12, Vol.225, p.1-8
Main Authors: Olausson, P, Venkitaramani, D.V, Moran, T.D, Salter, M.W, Taylor, J.R, Lombroso, P.J
Format: Article
Language:English
Subjects:
Amygdala - cytology
Amygdala - metabolism
Analysis of Variance
Anatomical correlates of behavior
Animals
Behavioral psychophysiology
Biological and medical sciences
Biophysics
Conditioning, Operant - physiology
Electric Stimulation
ERK
Excitatory Postsynaptic Potentials - genetics
Fear - physiology
fear conditioning
Fundamental and applied biological sciences. Psychology
long-term potentiation
Male
MAP Kinase Signaling System - genetics
Memory - physiology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Neurology
Neuronal Plasticity - genetics
Neuronal Plasticity - physiology
Patch-Clamp Techniques
protein tyrosine phosphatase
Protein Tyrosine Phosphatases, Non-Receptor - genetics
Protein Tyrosine Phosphatases, Non-Receptor - metabolism
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Reinforcement (Psychology)
Reinforcement Schedule
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Summary:Highlights ► The protein phosphatase STEP regulates signaling proteins involved in neuroplasticity. ► The effect of STEP on neuroplasticity was examined in genetically modified mice. ► STEP deletion facilitates fear learning in mice. ► STEP deletion increases ERK activity in the basolateral amygdala. ► STEP deletion facilitates long-term potentiation in the lateral amygdala.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.07.069