Cytotoxicity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine

Aim. The present study was designed to investigate the cytotoxicity of a panel of 280 Korean medicinal plants belonging to 73 families and 198 species against human CCRF-CEM leukemia cells. Selected phytochemicals were investigated in more detail for their mode of action. Methods. The resazurin assa...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2013-01, Vol.2013 (2013), p.1-14
Main Authors: Kuete, Victor, Seo, Ean-Jeong, Krusche, Benjamin, Oswald, Mira, Wiench, Benjamin, Schroeder, Sven, Greten, Henry Johannes, Lee, Ik-Soo, Efferth, Thomas
Format: Article
Language:English
Subjects:
Biological activity
Cancer
Cluster analysis
Cytotoxicity
DNA microarrays
Drugs
Functional groups
Gene expression
Gene regulation
Herbal medicine
Leukemia
Medicinal plants
Medicine
Metabolism
Mode of action
Pharmaceuticals
Pharmacogenomics
Phytochemicals
Plant extracts
Sarcoplasmic reticulum
Sedum
Toxicity testing
Transcription
Transduction
Tumor cell lines
Tumors
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Summary:Aim. The present study was designed to investigate the cytotoxicity of a panel of 280 Korean medicinal plants belonging to 73 families and 198 species against human CCRF-CEM leukemia cells. Selected phytochemicals were investigated in more detail for their mode of action. Methods. The resazurin assay was used to determine cytotoxicity of the plant extracts. Microarray-based mRNA expression profiling, COMPARE, and hierarchical cluster analyses were applied to identify which genes correlate with sensitivity or resistance to selected phytochemicals of the Korean plants. Results. The results of the resazurin assay showed that cytotoxicity extracts tested at 10 μg/mL from 13 samples inhibited proliferation more than 50% (IC50
ISSN:1741-427X
1741-4288
DOI:10.1155/2013/341724