Release behavior and toxicity profiles towards A549 cell lines of ciprofloxacin from its layered zinc hydroxide intercalation compound

Background Layered hydroxides salts (LHS), a layered inorganic compound is gaining attention in a wide range of applications, particularly due to its unique anion exchange properties. In this work, layered zinc hydroxide nitrate (LZH), a family member of LHS was intercalated with anionic ciprofloxac...

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Bibliographic Details
Published in:BMC chemistry 2013-07, Vol.7 (1), p.119-119, Article 119
Main Authors: Abdul Latip, Ahmad Faiz, Hussein, Mohd Zobir, Stanslas, Johnson, Wong, Charng Choon, Adnan, Rohana
Format: Article
Language:English
Subjects:
Acids
Anions
Aqueous solutions
Cell culture
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Drug delivery systems
Fourier transforms
Health sciences
Hydroxides
Intercalation compounds
Ion exchangers
Materials and Polymers
Molecular weight
Nanoparticles
Nanostructured materials
Nitrates
Research Article
Texture
Thermogravimetric analysis
Toxicity
Zinc
Zinc oxides
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Summary:Background Layered hydroxides salts (LHS), a layered inorganic compound is gaining attention in a wide range of applications, particularly due to its unique anion exchange properties. In this work, layered zinc hydroxide nitrate (LZH), a family member of LHS was intercalated with anionic ciprofloxacin (CFX), a broad spectrum antibiotic via ion exchange in a mixture solution of water:ethanol. Results Powder x-ray diffraction (XRD), Fourier transform infrared (FTIR) and thermogravimetric analysis (TGA) confirmed the drug anions were successfully intercalated in the interlayer space of LZH. Specific surface area of the obtained compound was increased compared to that of the host due to the different pore textures between the two materials. CFX anions were slowly released over 80 hours in phosphate-buffered saline (PBS) solution due to strong interactions that occurred between the intercalated anions and the host lattices. The intercalation compound demonstrated enhanced antiproliferative effects towards A549 cancer cells compared to the toxicity of CFX alone. Conclusions Strong host-guest interactions between the LZH lattice and the CFX anion give rise to a new intercalation compound that demonstrates sustained release mode and enhanced toxicity effects towards A549 cell lines. These findings should serve as foundations towards further developments of the brucite-like host material in drug delivery systems.
ISSN:1752-153X
1752-153X
2661-801X
DOI:10.1186/1752-153X-7-119