Postage for the messenger: designating routes for nuclear mRNA export

Highlights • Multiple mRNA export mechanisms exist utilizing both NPC and NE-budding pathways. • RNA-intrinsic elements and mRNA adaptors specify the mRNA export pathway. • Pathways are differentially regulated during stress, disease, and development. • Recent evidence suggests that these export pat...

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Bibliographic Details
Published in:Trends in cell biology 2013-08, Vol.23 (8), p.365-373
Main Authors: Natalizio, Barbara J, Wente, Susan R
Format: Article
Language:English
Subjects:
Active Transport, Cell Nucleus
Animals
Cell Nucleus - metabolism
Disease
exportin
Humans
lamin
mRNA export
nuclear envelope
nuclear pore complex
Pathology
RNA Transport
RNA, Messenger - metabolism
Stress, Physiological
transport
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Summary:Highlights • Multiple mRNA export mechanisms exist utilizing both NPC and NE-budding pathways. • RNA-intrinsic elements and mRNA adaptors specify the mRNA export pathway. • Pathways are differentially regulated during stress, disease, and development. • Recent evidence suggests that these export pathways are functionally interconnected.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2013.03.006