Effect of endotoxin administration in pregnant camels

Intravenous administration of Escherichia coli endotoxin at a dose of 0.05 μg/kg bodyweight to pregnant camels resulted in abortion. The injection of endotoxin caused significant increases in the plasma concentration of 13,14-dihydro-15-prostaglandin F 2α, the metabolite of prostaglandin F 2α (PG F...

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Bibliographic Details
Published in:Saudi journal of biological sciences 2010-04, Vol.17 (2), p.101-103
Main Authors: AL-Dughaym, A.M., Homeida, A.M.
Format: Article
Language:English
Subjects:
Abortion
Camels
Cortisol
Endotoxin
Endotoxins
Original
Physiological effect
Physiology
Pregnancy
Pregnancy in animals
Progesterone
Prostaglandin
الإبل
الإنجاب
الحمل
الحيوانات
الفسيولوجيا
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Summary:Intravenous administration of Escherichia coli endotoxin at a dose of 0.05 μg/kg bodyweight to pregnant camels resulted in abortion. The injection of endotoxin caused significant increases in the plasma concentration of 13,14-dihydro-15-prostaglandin F 2α, the metabolite of prostaglandin F 2α (PG F 2α) and cortisol and a significant decrease in the concentration of progesterone. It is suggested that endotoxin caused abortion in camels was a consequence of endotoxin induced PG F 2α secretion resulting in luteal regression and decreased progesterone concentration.
ISSN:1319-562X
2213-7106
DOI:10.1016/j.sjbs.2010.02.002