A community-based sero-epidemiological study of hepatitis B infection in Lianyungang, China, 2010

• Published in: Western Pacific surveillance and response journal 2012-07, Vol.3 (3), p.69-75
• Main Authors: Ting-Lu, Zhang, Zhi-Ping, Xiao, Hong-Yu, Ling, Chang-Hong, Ge, Liang, Ying, Qiang, Ding, Kai-Ling, Xu, Yan-Ming, Mao, Yue-He, Du, Ling-Yang, Zhu
• Format: Article
• Language: English
• Subjects: Other Topic
• ISSN: 2094-7321; 2094-7313
• DOI: 10.5365/WPSAR.2011.2.1.008

The 2010 targets of the China Hepatitis B Prevention Programme were a prevalence of hepatitis B surface antigen (HBsAg) less than 1.0% for children less than five years old and less than 6.0% for the total population. This survey assessed the prevalence of Hepatitis B infection in Lianyungang, Jiangsu province, China in 2009-2010. Multistage sampling was used with 2372 subjects among 17 selected villages. Blood specimen collection and testing by enzyme-linked immunosorbnet assay (ELISA) were completed using the following markers for hepatitis infection: HBsAg and antibody to HBsAg (anti-HBs); hepatitis B e antigen (HBeAg) and antibody to HBeAg (anti-HBe); and hepatitis B core antibody (total anti-HBc). The data were analysed with Epi Info, version 3.3.2. The prevalence of HBsAg was 2.4% (95% Confidence Interval [CI]: 1.8-3.0; Adjusted Prevalence [AP] 2.9%); anti-HBs prevalence was 51.1% (95% CI: 49.1-53.1; AP 49.2%) and total anti-HBc prevalence was 41.7% (95% CI: 39.8-43.7; AP 45.5%). The prevalence of HBsAg and total anti-HBc positivity increased from young to older age groups, yet the prevalence of anti-HBs positivity decreased from young to older age groups (P