A compendium of molecules involved in vector-pathogen interactions pertaining to malaria

Malaria is a vector-borne disease causing extensive morbidity, debility and mortality. Development of resistance to drugs among parasites and to conventional insecticides among vector-mosquitoes necessitates innovative measures to combat this disease. Identification of molecules involved in the main...

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Bibliographic Details
Published in:Malaria journal 2013-06, Vol.12 (1), p.216-216, Article 216
Main Authors: Sreenivasamurthy, Sreelakshmi K, Dey, Gourav, Ramu, Manjula, Kumar, Manish, Gupta, Manoj K, Mohanty, Ajeet K, Harsha, H C, Sharma, Pushkar, Kumar, Nirbhay, Pandey, Akhilesh, Kumar, Ashwani, Prasad, T S Keshava
Format: Article
Language:English
Subjects:
Animals
Anopheles
Aquatic insects
Culicidae - parasitology
Disease transmission
Disease Vectors
Gastrointestinal Tract - parasitology
Genetic engineering
Health aspects
Hemolymph - parasitology
Host-Parasite Interactions
India
Insect Proteins - genetics
Insect Proteins - metabolism
Insecticides
Malaria
Mortality
Mosquitoes
Parasites
Pathogens
Plasmodium - physiology
Plasmodium falciparum
Proteins
Review
Risk factors
Salivary Glands - parasitology
United States
Vector-borne diseases
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Summary:Malaria is a vector-borne disease causing extensive morbidity, debility and mortality. Development of resistance to drugs among parasites and to conventional insecticides among vector-mosquitoes necessitates innovative measures to combat this disease. Identification of molecules involved in the maintenance of complex developmental cycles of the parasites within the vector and the host can provide attractive targets to intervene in the disease transmission. In the last decade, several efforts have been made in identifying such molecules involved in mosquito-parasite interactions and, subsequently, validating their role in the development of parasites within the vector. In this study, a list of mosquito proteins, which facilitate or inhibit the development of malaria parasites in the midgut, haemolymph and salivary glands of mosquitoes, is compiled. A total of 94 molecules have been reported and validated for their role in the development of malaria parasites inside the vector. This compendium of molecules will serve as a centralized resource to biomedical researchers investigating vector-pathogen interactions and malaria transmission.
ISSN:1475-2875
1475-2875
DOI:10.1186/1475-2875-12-216