Effect of Lycopersicon esculentum extract on apoptosis in the rat cerebellum, following prenatal and postnatal exposure to an electromagnetic field

The expansion of mobile phone technology has raised concerns regarding the effect of 900-MHz electromagnetic field (EMF) exposure on the central nervous system. At present, the developing human brain is regularly exposed to mobile telephones, pre- and postnatally. Several studies have demonstrated t...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2013-07, Vol.6 (1), p.52-56
Main Authors: KÖKTÜRK, SIBEL, YARDIMOGLU, MELDA, CELIKOZLU, SAADET D, DOLANBAY, ELIF GELENLI, CIMBIZ, ALI
Format: Article
Language:English
Subjects:
Antioxidants
Apoptosis
Brain
Carotenoids
cerebellum
electromagnetic field
Electromagnetism
Lycopersicon esculentum
mobile phone
Nervous system
Neurodegeneration
Neurotoxicity
Rodents
Statistical analysis
Studies
Tomatoes
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Summary:The expansion of mobile phone technology has raised concerns regarding the effect of 900-MHz electromagnetic field (EMF) exposure on the central nervous system. At present, the developing human brain is regularly exposed to mobile telephones, pre- and postnatally. Several studies have demonstrated the acute effects of EMF exposure during pre- or postnatal periods; however, the chronic effects of EMF exposure are less understood. Thus, the aim of the present study was to determine the chronic effects of EMF on the pre- and postnatal rat cerebellum. The control group was maintained in the same conditions as the experimental groups, without the exposure to EMF. In the EMF1 group, the rats were exposed to EMF during pre- and postnatal periods (until postnatal day 80). In the EMF2 group, the rats were also exposed to EMF pre- and postnatally; in addition, however, they were provided with a daily oral supplementation of Lycopersicon esculentum extract (∼2 g/kg). The number of caspase-3-labeled Purkinje neurons and granule cells present in the rats in the control and experimental groups were then counted. The neurodegenerative changes were studied using cresyl violet staining, and these changes were evaluated. In comparison with the control animals, the EMF1 group demonstrated a significant increase in the number of caspase-3-labeled Purkinje neurons and granule cells present in the cerebellum (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2013.1123