Acute reduction of lipolysis reduces adiponectin and IL-18: evidence from an intervention study with acipimox and insulin

Aims/hypothesis Low-grade inflammation is a feature of chronic diseases such as type 2 diabetes and lipodystrophy. It is associated with abdominal adiposity, increased levels of NEFA, hyperinsulinaemia and low adiponectin levels. However, the causal relationship between impaired metabolism and infla...

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Bibliographic Details
Published in:Diabetologia 2013-09, Vol.56 (9), p.2034-2043
Main Authors: Lindegaard, B., Ditlevsen, S., Plomgaard, P., Mittendorfer, B., Pedersen, B. K.
Format: Article
Language:English
Subjects:
Adipocytes
Adiponectin - blood
Biological and medical sciences
Body fat
Cross-Over Studies
Cytokines
Dermatology
Diabetes
Diabetes. Impaired glucose tolerance
Drug therapy
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
HIV
Human immunodeficiency virus
Human Physiology
Humans
Hypotheses
Infectious diseases
Inflammation
Insulin - therapeutic use
Insulin resistance
Interleukin-18 - blood
Internal Medicine
Kinases
Lipodystrophy - blood
Lipodystrophy - drug therapy
Lipolysis - drug effects
Male
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolism
Middle Aged
Plasma
Proteins
Pyrazines - therapeutic use
Skin involvement in other diseases. Miscellaneous. General aspects
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Summary:Aims/hypothesis Low-grade inflammation is a feature of chronic diseases such as type 2 diabetes and lipodystrophy. It is associated with abdominal adiposity, increased levels of NEFA, hyperinsulinaemia and low adiponectin levels. However, the causal relationship between impaired metabolism and inflammation is not understood. We explored the anti-lipolytic effect of acipimox and insulin on adiponectin and adipocyte-associated cytokines in patients with lipodystrophy. Methods In a randomised placebo-controlled crossover design using nine patients with non-diabetic, HIV-associated lipodystrophy, we assessed whether (1) overnight administration of a low dose of acipimox and/or (2) insulin-induced suppression of NEFA flux altered circulating plasma levels of adiponectin, IL-18, TNF-α and IL-6 in the basal condition and in a two-stage euglycaemic–hyperinsulinaemic clamp combined with stable isotopes (insulin infusion rates 20 mU m −2  min −1 and 50 mU m −2  min −1 ). Results Insulin decreased plasma NEFA in a dose-dependent manner ( p  
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-013-2964-3