Dual Responsive, Stabilized Nanoparticles for Efficient In Vivo Plasmid Delivery

A small case of love and hate: A block‐statistical copolymer combining reversible hydrophobization and statistical hydrophilization allows the preparation of pH value‐ and reduction‐responsive nanoparticles (polyplexes) for efficient in vivo plasmid delivery.

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2013-05, Vol.52 (20), p.5377-5381
Main Authors: Wei, Hua, Volpatti, Lisa R., Sellers, Drew L., Maris, Don O., Andrews, Ian W., Hemphill, Ashton S., Chan, Leslie W., Chu, David S. H., Horner, Philip J., Pun, Suzie H.
Format: Article
Language:English
Subjects:
copolymers
DNA nanoparticles
Drug Carriers - chemistry
Drug Stability
Endocytosis
Endosomes - metabolism
gene transfection
Gene Transfer Techniques
HeLa Cells
Humans
hydrophilization
Hydrophobic and Hydrophilic Interactions
hydrophobization
Microscopy, Electron, Transmission
Nanoparticles - chemistry
Plasmids - administration & dosage
Plasmids - genetics
Polymers - chemistry
RNA, Small Interfering - administration & dosage
RNA, Small Interfering - genetics
Surface Properties
Transfection
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Description
Summary:A small case of love and hate: A block‐statistical copolymer combining reversible hydrophobization and statistical hydrophilization allows the preparation of pH value‐ and reduction‐responsive nanoparticles (polyplexes) for efficient in vivo plasmid delivery.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201301896