Virologic response and resistance to lamivudine in patients with chronic hepatitis B: a ten-year retrospective analysis

Emergence of resistance was recognized shortly after the introduction of lamivudine. This 10 year retrospective study investigates resistance to lamivudine and the modifications of antiviral strategies required. Two hundred and nine patients were treated with lamivudine. Sixty seven out of 209 patie...

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Published in:Hippokratia 2012-01, Vol.16 (4), p.342-346
Main Authors: Gigi, E, Sykia, A, Sinakos, E, Koumerkeridis, G, Raptopoulou-Gigi, M, Bellou, Al, Mougiou, D, Orfanou, E, Vrettou, E
Format: Article
Language:English
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Summary:Emergence of resistance was recognized shortly after the introduction of lamivudine. This 10 year retrospective study investigates resistance to lamivudine and the modifications of antiviral strategies required. Two hundred and nine patients were treated with lamivudine. Sixty seven out of 209 patients were excluded from the present study. HBVDNA was tested using the PCR assay and genotypic resistance was performed using the direct PCR sequencing. In the 125 patients initially treated with lamivudine monotherapy: Α) 48 (38.4%) patients with a mean time of 63.6±26.2 months under lamivudine treatment have normal ALT levels with negative (19%) or low (
ISSN:1108-4189
1790-8019