Inflammatory cytokines in depression: Neurobiological mechanisms and therapeutic implications

Highlights • Symptoms of cytokine-related depression may involve specific genes, neurotransmitters. • Environmental factors (e.g. childhood trauma, stress, obesity) increase cytokines. • Novel treatments for depression may target cytokines and their signaling mechanisms.

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Bibliographic Details
Published in:Neuroscience 2013-08, Vol.246, p.199-229
Main Authors: Felger, J.C, Lotrich, F.E
Format: Article
Language:English
Subjects:
Animals
Antidepressive Agents - pharmacology
Antidepressive Agents - therapeutic use
Biological and medical sciences
Biomarkers - metabolism
Brain - drug effects
Brain - metabolism
brain-derived neurotrophic factor
Cytokines - metabolism
depression
Depression - diagnosis
Depression - metabolism
Depression - therapy
dopamine
Fundamental and applied biological sciences. Psychology
Humans
Inflammation - diagnosis
Inflammation - metabolism
Inflammation - therapy
Inflammation Mediators - antagonists & inhibitors
Inflammation Mediators - metabolism
inflammatory cytokines
kynurenines
Neurology
serotonin
Vertebrates: nervous system and sense organs
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Description
Summary:Highlights • Symptoms of cytokine-related depression may involve specific genes, neurotransmitters. • Environmental factors (e.g. childhood trauma, stress, obesity) increase cytokines. • Novel treatments for depression may target cytokines and their signaling mechanisms.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.04.060