The Influence of Gene-Gene and Gene-Environment Interactions on the Risk of Asbestosis

This study investigated the influence of gene-gene and gene-environment interactions on the risk of developing asbestosis. The study comprised 262 cases with asbestosis and 265 controls with no asbestos-related disease previously studied for MnSOD, ECSOD, CAT, GSTT1, GSTM1, GSTP1, and iNOS polymorph...

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Bibliographic Details
Published in:BioMed research international 2013-01, Vol.2013 (2013), p.1-7
Main Authors: Dodič-Fikfak, Metoda, Arnerić, Niko, Dolžan, Vita, Franko, Alenka
Format: Article
Language:English
Subjects:
Asbestos
Asbestosis
Asbestosis - enzymology
Asbestosis - genetics
Case-Control Studies
Catalase - genetics
Disease
Enzymes
Epistasis, Genetic
Female
Gene-Environment Interaction
Genes
Genetic polymorphisms
Genetic Predisposition to Disease
Glutathione S-Transferase pi - genetics
Glutathione Transferase - genetics
Health aspects
Humans
Logistic Models
Male
Medicine
Membrane filters
Middle Aged
Nitric oxide
Nitric Oxide Synthase Type II - genetics
Occupational diseases
Outdoor air quality
Pathogenesis
Polymorphism
Research Article
Risk Factors
Smoking
Smoking - genetics
Studies
Superoxide Dismutase - genetics
Workers
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Summary:This study investigated the influence of gene-gene and gene-environment interactions on the risk of developing asbestosis. The study comprised 262 cases with asbestosis and 265 controls with no asbestos-related disease previously studied for MnSOD, ECSOD, CAT, GSTT1, GSTM1, GSTP1, and iNOS polymorphisms. Data on cumulative asbestos and smoking were available for all subjects. To assess gene-gene and gene-environmental interactions, logistic regression was used. The associations between MnSOD Ala −9Val polymorphism and the risk of asbestosis and between iNOS genotypes and asbestosis were modified by CAT –262 C > T polymorphism (P=0.038;P=0.031). A strong interaction was found between GSTM1-null polymorphism and smoking (P=0.007), iNOS (CCTTT)n polymorphism and smoking (P=0.054), and between iNOS (CCTTT)n polymorphism and cumulative asbestos exposure (P=0.037). The findings of this study suggest that the interactions between different genotypes, genotypes and smoking, and between genotypes and asbestos exposure have an important influence on the development of asbestosis and should be seriously considered in future research on occupational/environmental asbestos-related diseases.
ISSN:2314-6133
2314-6141
DOI:10.1155/2013/405743