Increased malondialdehyde concentration and reduced total antioxidant capacity in aqueous humor and blood samples from patients with glaucoma

To evaluate the levels of malondialdehyde (MDA) and total antioxidant capacity (TAC) in the blood and aqueous humor of glaucomatous and nonglaucomatous patients. To measure the adenosine triphosphate/adenosine diphosphate/adenosine monophosphate (ATP/ADP/AMP) concentration as a biomarker of the bloo...

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Bibliographic Details
Published in:Molecular vision 2013-08, Vol.19, p.1841-1846
Main Authors: Nucci, Carlo, Di Pierro, Donato, Varesi, Chiara, Ciuffoletti, Elena, Russo, Rossella, Gentile, Rocco, Cedrone, Claudio, Pinazo Duran, Maria Dolores, Coletta, Massimiliano, Mancino, Raffaele
Format: Article
Language:English
Subjects:
Aged
Antioxidants - metabolism
Aqueous Humor - metabolism
Case-Control Studies
Female
Glaucoma - blood
Glaucoma - metabolism
Humans
Male
Malondialdehyde - blood
Malondialdehyde - metabolism
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Summary:To evaluate the levels of malondialdehyde (MDA) and total antioxidant capacity (TAC) in the blood and aqueous humor of glaucomatous and nonglaucomatous patients. To measure the adenosine triphosphate/adenosine diphosphate/adenosine monophosphate (ATP/ADP/AMP) concentration as a biomarker of the blood energy charge potential. We examined 40 consecutive patients with primary open-angle glaucoma scheduled for cataract surgery. Twenty-six age-matched subjects scheduled for cataract surgery were enrolled as a control group. Blood and aqueous humor samples were collected at the time of surgery. MDA concentrations and blood nucleotides were measured with high-performance liquid chromatography. The TAC of the samples was estimated with the oxygen-radical absorbance capacity method. Blood and aqueous humor MDA levels in glaucoma patients (respectively, 0.976±0.370 and 0.145±0.065 μmol/ml) were significantly increased (p
ISSN:1090-0535