Transduction of voltage and Ca2+ signals by Slo1 BK channels

Large-conductance Ca2+ -and voltage-gated K+ channels are activated by an increase in intracellular Ca2+ concentration and/or depolarization. The channel activation mechanism is well described by an allosteric model encompassing the gate, voltage sensors, and Ca2+ sensors, and the model is an excell...

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Bibliographic Details
Published in:Physiology (Bethesda, Md.) Md.), 2013-05, Vol.28 (3), p.172-189
Main Authors: Hoshi, T, Pantazis, A, Olcese, R
Format: Article
Language:English
Subjects:
Animals
Binding Sites
Calcium Signaling
Humans
Ion Channel Gating
Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - chemistry
Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - metabolism
Membrane Potentials
Models, Biological
Models, Molecular
Protein Binding
Protein Conformation
Reviews
Structure-Activity Relationship
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Summary:Large-conductance Ca2+ -and voltage-gated K+ channels are activated by an increase in intracellular Ca2+ concentration and/or depolarization. The channel activation mechanism is well described by an allosteric model encompassing the gate, voltage sensors, and Ca2+ sensors, and the model is an excellent framework to understand the influences of auxiliary β and γ subunits and regulatory factors such as Mg2+. Recent advances permit elucidation of structural correlates of the biophysical mechanism.
ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.00055.2012