Gene expression analysis of aberrant signaling pathways in meningiomas

Examining aberrant pathway alterations is one method for understanding the abnormal signals that are involved in tumorigenesis and tumor progression. In the present study, expression arrays were performed on tumor-related genes in meningiomas. The GE Array Q Series HS-006 was used to determine the e...

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Bibliographic Details
Published in:Oncology letters 2013-07, Vol.6 (1), p.275-279
Main Authors: TORRES-MARTÍN, MIGUEL, MARTINEZ-GLEZ, VICTOR, PEÑA-GRANERO, CAROLINA, ISLA, ALBERTO, LASSALETTA, LUIS, DE CAMPOS, JOSE M, PINTO, GIOVANNY R, BURBANO, ROMMEL R, MELÉNDEZ, BÁRBARA, CASTRESANA, JAVIER S, REY, JUAN A
Format: Article
Language:English
Subjects:
Angiogenesis
Apoptosis
Brain cancer
Cell cycle
Cytokines
Deoxyribonucleic acid
DNA
DNA damage
Gene expression
gene expression arrays
Growth factors
meningioma
Metastasis
Mutation
neurofibromin gene
Oncology
schwannoma
Senescence
Signal transduction
signaling pathways
Tumorigenesis
Tumors
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Summary:Examining aberrant pathway alterations is one method for understanding the abnormal signals that are involved in tumorigenesis and tumor progression. In the present study, expression arrays were performed on tumor-related genes in meningiomas. The GE Array Q Series HS-006 was used to determine the expression levels of 96 genes that corresponded to six primary biological regulatory pathways in a series of 42 meningiomas, including 32 grade I, four recurrent grade I and six grade II tumors, in addition to three normal tissue controls. Results showed that 25 genes that were primarily associated with apoptosis and angiogenesis functions were downregulated and 13 genes frequently involving DNA damage repair functions were upregulated. In addition to the inactivation of the neurofibromin gene, NF2, which is considered to be an early step in tumorigenesis, variations of other biological regulatory pathways may play a significant role in the development of meningioma.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2013.1363