The Flavoprotein Dodecin as a Redox Probe for Electron Transfer through DNA

Flavin away: Dodecin binds oxidized flavins, whereas reduction of the bound flavin induces dissociation of the holoprotein into apododecin and free flavins. The stepwise reconstitution of dodecin on flavin‐terminated ds‐DNA monolayers showed that although electrochemical flavin reduction (i.e. elect...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2013-04, Vol.52 (18), p.4950-4953
Main Authors: Yu, Yaming, Heidel, Björn, Parapugna, Tamara Lourdes, Wenderhold-Reeb, Sabine, Song, Bo, Schönherr, Holger, Grininger, Martin, Nöll, Gilbert
Format: Article
Language:English
Subjects:
Communications
Deoxyribonucleic acid
DNA
DNA - chemistry
dodecin
Electrochemical Techniques
Electrodes
Electron transfer
Electron Transport
flavin
Flavins - chemistry
Flavoproteins - chemistry
Flavoproteins - metabolism
Kinetics
Monolayers
Oxidation-Reduction
Reduction
Reduction (chemical)
Surface Plasmon Resonance
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Summary:Flavin away: Dodecin binds oxidized flavins, whereas reduction of the bound flavin induces dissociation of the holoprotein into apododecin and free flavins. The stepwise reconstitution of dodecin on flavin‐terminated ds‐DNA monolayers showed that although electrochemical flavin reduction (i.e. electron transfer through DNA) was not possible, apododecin (gray circles) could be released by chemical reduction (see scheme).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201208987