Notching Up MYC Gives a LIC

In a recent issue of Cell, King et al. (2013) show that mutations in the ubiquitin ligase subcomponent FBXW7 increase MYC protein levels and expand the number of leukemia-initiating cells (LICs) in Notch1-induced T-ALL. Genetic and pharmacological inhibition of MYC abolishes LIC activity with broade...

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Bibliographic Details
Published in:Cell stem cell 2013-07, Vol.13 (1), p.8-9
Main Authors: Levens, David, Aplan, Peter D.
Format: Article
Language:English
Subjects:
Animals
Cell Cycle Proteins - metabolism
F-Box Proteins - metabolism
Humans
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism
Proto-Oncogene Proteins c-myc - metabolism
Ubiquitin-Protein Ligases - metabolism
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Summary:In a recent issue of Cell, King et al. (2013) show that mutations in the ubiquitin ligase subcomponent FBXW7 increase MYC protein levels and expand the number of leukemia-initiating cells (LICs) in Notch1-induced T-ALL. Genetic and pharmacological inhibition of MYC abolishes LIC activity with broader therapeutic implications.
ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2013.06.008