Pinocembrin: A Novel Natural Compound with Versatile Pharmacological and Biological Activities

Pinocembrin (5,7-dihydroxyflavanone) is one of the primary flavonoids isolated from the variety of plants, mainly from Pinus heartwood, Eucalyptus, Populus, Euphorbia, and Sparattosperma leucanthum, in the diverse flora and purified by various chromatographic techniques. Pinocembrin is a major flavo...

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Bibliographic Details
Published in:BioMed research international 2013-01, Vol.2013 (2013), p.1-9
Main Authors: Li, Jiang, Ali, M., Ali Eltayb, Wafa, Millimouno, Faya Martin, Rasul, Azhar, Li, Xiaomeng
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents - pharmacology
Anti-Inflammatory Agents - pharmacology
Antimicrobial agents
Antineoplastic Agents - pharmacology
Bioflavonoids
Biological Products - pharmacology
Chromatography
Eucalyptus
Flavanones - chemistry
Flavanones - pharmacology
Flavones
Flavonoids
Health aspects
Humans
Materia medica, Vegetable
Pharmacology
Plant extracts
Review
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Summary:Pinocembrin (5,7-dihydroxyflavanone) is one of the primary flavonoids isolated from the variety of plants, mainly from Pinus heartwood, Eucalyptus, Populus, Euphorbia, and Sparattosperma leucanthum, in the diverse flora and purified by various chromatographic techniques. Pinocembrin is a major flavonoid molecule incorporated as multifunctional in the pharmaceutical industry. Its vast range of pharmacological activities has been well researched including antimicrobial, anti-inflammatory, antioxidant, and anticancer activities. In addition, pinocembrin can be used as neuroprotective against cerebral ischemic injury with a wide therapeutic time window, which may be attributed to its antiexcitotoxic effects. Pinocembrin exhibits pharmacological effects on almost all systems, and our aim is to review the pharmacological and therapeutic applications of pinocembrin with specific emphasis on mechanisms of actions. The design of new drugs based on the pharmacological effects of pinocembrin could be beneficial. This review suggests that pinocembrin is a potentially promising pharmacological candidate, but additional studies and clinical trials are required to determine its specific intracellular sites of action and derivative targets in order to fully understand the mechanism of its anti-inflammatory, anticancer, and apoptotic effects to further validate its medical applications.
ISSN:2314-6133
2314-6141
DOI:10.1155/2013/379850