Impaired Leg Vasodilatory Function After Stroke: Adaptations With Treadmill Exercise Training

Resting and reactive hyperemic leg blood flows are significantly reduced in the paretic compared with the nonparetic limb after disabling stroke. Our objective was to compare the effects of regular treadmill exercise (TM) with an active control regimen of supervised stretching (CONTROL) on periphera...

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Bibliographic Details
Published in:Stroke (1970) 2010-12, Vol.41 (12), p.2913-2917
Main Authors: IVEY, Frederick M, HAFER-MACKO, Charlene E, RYAN, Alice S, MACKO, Richard F
Format: Article
Language:English
Subjects:
Adaptation, Physiological - physiology
Aged
Biological and medical sciences
Exercise Test
Exercise Therapy
Female
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Leg - blood supply
Leg - physiopathology
Male
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Neurology
Paresis - physiopathology
Paresis - rehabilitation
Physical Fitness
Plethysmography
Regional Blood Flow - physiology
Stroke - physiopathology
Stroke Rehabilitation
Vascular diseases and vascular malformations of the nervous system
Vasodilation - physiology
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Summary:Resting and reactive hyperemic leg blood flows are significantly reduced in the paretic compared with the nonparetic limb after disabling stroke. Our objective was to compare the effects of regular treadmill exercise (TM) with an active control regimen of supervised stretching (CONTROL) on peripheral hemodynamic function. This intervention study used a randomized, controlled design, in which participants were randomized with stratification according to age and baseline walking capacity to ensure approximate balance between the 2 groups. Fifty-three chronic, ischemic stroke participants (29 TM and 24 CONTROL) with mild to moderate hemiparetic gait completed bilateral measurements of lower leg resting and reactive hyperemic blood flow using venous occlusion strain gauge plethysmography before and after the 6-month intervention period. Participants also underwent testing to track changes in peak aerobic fitness across time. Resting and reactive hyperemic blood flows were significantly reduced in the paretic compared with the nonparetic limb at baseline before any intervention (-28% and -34%, respectively, P
ISSN:0039-2499
1524-4628
1524-4628
DOI:10.1161/STROKEAHA.110.599977