The co-expression of functional gastric proteins in dynamic gastric diseases and its clinical significance

Pepsinogen C (PGC) and mucin1 (MUC1) are important physiologically functional gastric proteins; Mucin2 (MUC2) is an "ectopic" functional protein in intestinal metaplasia of gastric mucosa. We analyzed the co-expression of the above-mentioned three proteins in dynamic gastric diseases {supe...

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Bibliographic Details
Published in:BMC clinical pathology 2013-08, Vol.13 (1), p.21-21, Article 21
Main Authors: Xu, Qian, Sun, Li-Ping, Wang, Ben-Gang, Liu, Jing-Wei, Li, Ping, He, Cai-Yun, Yuan, Yuan
Format: Article
Language:English
Subjects:
Age
Agricultural societies
Biomarkers
Biopsy
Development and progression
Family medical history
Gastric cancer
Gender
Genotype & phenotype
Hospitals
Mucins
Proteins
Shenyang (opera singer)
Stomach cancer
Surgery
Tumors
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Summary:Pepsinogen C (PGC) and mucin1 (MUC1) are important physiologically functional gastric proteins; Mucin2 (MUC2) is an "ectopic" functional protein in intestinal metaplasia of gastric mucosa. We analyzed the co-expression of the above-mentioned three proteins in dynamic gastric diseases {superficial gastritis (SG)-atrophic gastritis (AG)--gastric cancer (GC)} as well as different histological types of gastric cancer in order to find molecular phenotypes of gastric cancer and precancerous disease and further explore the potential co-function of PGC, MUC1 and MUC2 in the occurrence and development of gastric cancer. The SG-AG-GC sequence was 57-57-70 cases in this case-control study, respectively. Different histological types of GC were 28 cases of highly and moderately differentiated aden ocarcinoma (HMDA)、30 of poorly differentiated adenocarcinoma (PDA) and 12 of mucinous adenocarcinoma (MA) or signet ring cell carcinoma (SRCC). PGC, MUC1 and MUC2 expression in situ were detected in all 184 cases using immunohistochemistry. Both PGC and MUC1 had a significantly decreased expression in GC than in SG and AG (P 
ISSN:1472-6890
1472-6890
DOI:10.1186/1472-6890-13-21