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Critical role of leukotriene B4 receptor signaling in mouse 3T3-L1 preadipocyte differentiation
Various inflammatory mediators related to obesity might be closely related to insulin resistance. Leukotrienes (LTs) are involved in inflammatory reactions. However, there are few reports regarding the role of LTs in adipocyte differentiation. Therefore, we investigated the role of leukotriene B4 (L...
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| Published in: | Lipids in health and disease 2013-08, Vol.12 (1), p.122-122, Article 122 |
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| creator | Hirata, Kae Wada, Koichiro Murata, Yuka Nakajima, Atsushi Yamashiro, Takashi Kamisaki, Yoshinori |
| description | Various inflammatory mediators related to obesity might be closely related to insulin resistance. Leukotrienes (LTs) are involved in inflammatory reactions. However, there are few reports regarding the role of LTs in adipocyte differentiation. Therefore, we investigated the role of leukotriene B4 (LTB4)-leukotriene receptor (BLT) signaling in mouse 3T3-L1 fibroblastic preadipocyte differentiation to mature adipocytes.
Mouse 3T3-L1 preadipocytes were treated with lipoxygenase (LOX) inhibitors, BLT antagonist, and small interfering RNA (siRNA) for BLT1 and BLT2 to block the LTB4-BLT signaling pathway, then the adipocyte differentiation such as lipid accumulation and the increase in triglyceride was evaluated.
Blockade of BLT signaling by treatment with a LOX inhibitor or a BLT antagonist suppressed preadipocyte differentiation into mature adipocytes. In addition, knockdown of BLT1 and BLT2 by siRNAs dramatically inhibited differentiation. These results indicate the LTB4-BLT signaling pathway may positively regulate preadipocyte differentiation and be a rate-limiting system to control adipocyte differentiation.
The LTB4-BLT signaling pathway provides a potent regulatory signal that accelerates the differentiation of mouse 3T3-L1 preadipocytes. Further investigations are necessary to confirm the exact role of LTB4 and BLTs signaling pathways in preadipocyte differentiation. |
| doi_str_mv | 10.1186/1476-511X-12-122 |
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Mouse 3T3-L1 preadipocytes were treated with lipoxygenase (LOX) inhibitors, BLT antagonist, and small interfering RNA (siRNA) for BLT1 and BLT2 to block the LTB4-BLT signaling pathway, then the adipocyte differentiation such as lipid accumulation and the increase in triglyceride was evaluated.
Blockade of BLT signaling by treatment with a LOX inhibitor or a BLT antagonist suppressed preadipocyte differentiation into mature adipocytes. In addition, knockdown of BLT1 and BLT2 by siRNAs dramatically inhibited differentiation. These results indicate the LTB4-BLT signaling pathway may positively regulate preadipocyte differentiation and be a rate-limiting system to control adipocyte differentiation.
The LTB4-BLT signaling pathway provides a potent regulatory signal that accelerates the differentiation of mouse 3T3-L1 preadipocytes. Further investigations are necessary to confirm the exact role of LTB4 and BLTs signaling pathways in preadipocyte differentiation.</description><identifier>ISSN: 1476-511X</identifier><identifier>EISSN: 1476-511X</identifier><identifier>DOI: 10.1186/1476-511X-12-122</identifier><identifier>PMID: 23937951</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>3T3-L1 Cells ; Adipocytes ; Adipocytes - drug effects ; Adipocytes - metabolism ; Analysis ; Animals ; Cell Differentiation - drug effects ; Cell Differentiation - genetics ; Cell growth ; Control systems ; Dentistry ; Experiments ; Health aspects ; Insulin resistance ; Insulin Resistance - genetics ; Leukotriene B4 - genetics ; Leukotriene B4 - metabolism ; Leukotrienes ; Lipids ; Lipoxygenase - genetics ; Lipoxygenase - metabolism ; Lipoxygenase Inhibitors - administration & dosage ; Mice ; Obesity ; Obesity - genetics ; Obesity - metabolism ; Obesity - pathology ; Pharmaceutical industry ; Proteins ; Receptors, Leukotriene B4 - genetics ; Receptors, Leukotriene B4 - metabolism ; RNA, Small Interfering ; Rodents ; Signal Transduction - drug effects ; Signal Transduction - genetics ; Statistical analysis ; Synthesis ; Triglycerides</subject><ispartof>Lipids in health and disease, 2013-08, Vol.12 (1), p.122-122, Article 122</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 Hirata et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Hirata et al.; licensee BioMed Central Ltd. 2013 Hirata et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b547t-4d2ddd3e12144349ae6df56f1ffc2b73f6fcb7685b4be8cb82df6cc50770d3c23</citedby><cites>FETCH-LOGICAL-b547t-4d2ddd3e12144349ae6df56f1ffc2b73f6fcb7685b4be8cb82df6cc50770d3c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751075/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1426852251?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,25736,27907,27908,36995,36996,44573,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23937951$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hirata, Kae</creatorcontrib><creatorcontrib>Wada, Koichiro</creatorcontrib><creatorcontrib>Murata, Yuka</creatorcontrib><creatorcontrib>Nakajima, Atsushi</creatorcontrib><creatorcontrib>Yamashiro, Takashi</creatorcontrib><creatorcontrib>Kamisaki, Yoshinori</creatorcontrib><title>Critical role of leukotriene B4 receptor signaling in mouse 3T3-L1 preadipocyte differentiation</title><title>Lipids in health and disease</title><addtitle>Lipids Health Dis</addtitle><description>Various inflammatory mediators related to obesity might be closely related to insulin resistance. Leukotrienes (LTs) are involved in inflammatory reactions. However, there are few reports regarding the role of LTs in adipocyte differentiation. Therefore, we investigated the role of leukotriene B4 (LTB4)-leukotriene receptor (BLT) signaling in mouse 3T3-L1 fibroblastic preadipocyte differentiation to mature adipocytes.
Mouse 3T3-L1 preadipocytes were treated with lipoxygenase (LOX) inhibitors, BLT antagonist, and small interfering RNA (siRNA) for BLT1 and BLT2 to block the LTB4-BLT signaling pathway, then the adipocyte differentiation such as lipid accumulation and the increase in triglyceride was evaluated.
Blockade of BLT signaling by treatment with a LOX inhibitor or a BLT antagonist suppressed preadipocyte differentiation into mature adipocytes. In addition, knockdown of BLT1 and BLT2 by siRNAs dramatically inhibited differentiation. These results indicate the LTB4-BLT signaling pathway may positively regulate preadipocyte differentiation and be a rate-limiting system to control adipocyte differentiation.
The LTB4-BLT signaling pathway provides a potent regulatory signal that accelerates the differentiation of mouse 3T3-L1 preadipocytes. Further investigations are necessary to confirm the exact role of LTB4 and BLTs signaling pathways in preadipocyte differentiation.</description><subject>3T3-L1 Cells</subject><subject>Adipocytes</subject><subject>Adipocytes - drug effects</subject><subject>Adipocytes - metabolism</subject><subject>Analysis</subject><subject>Animals</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Differentiation - genetics</subject><subject>Cell growth</subject><subject>Control systems</subject><subject>Dentistry</subject><subject>Experiments</subject><subject>Health aspects</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - genetics</subject><subject>Leukotriene B4 - genetics</subject><subject>Leukotriene B4 - metabolism</subject><subject>Leukotrienes</subject><subject>Lipids</subject><subject>Lipoxygenase - genetics</subject><subject>Lipoxygenase - metabolism</subject><subject>Lipoxygenase Inhibitors - administration & dosage</subject><subject>Mice</subject><subject>Obesity</subject><subject>Obesity - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Lipids in health and disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hirata, Kae</au><au>Wada, Koichiro</au><au>Murata, Yuka</au><au>Nakajima, Atsushi</au><au>Yamashiro, Takashi</au><au>Kamisaki, Yoshinori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Critical role of leukotriene B4 receptor signaling in mouse 3T3-L1 preadipocyte differentiation</atitle><jtitle>Lipids in health and disease</jtitle><addtitle>Lipids Health Dis</addtitle><date>2013-08-09</date><risdate>2013</risdate><volume>12</volume><issue>1</issue><spage>122</spage><epage>122</epage><pages>122-122</pages><artnum>122</artnum><issn>1476-511X</issn><eissn>1476-511X</eissn><abstract>Various inflammatory mediators related to obesity might be closely related to insulin resistance. Leukotrienes (LTs) are involved in inflammatory reactions. However, there are few reports regarding the role of LTs in adipocyte differentiation. Therefore, we investigated the role of leukotriene B4 (LTB4)-leukotriene receptor (BLT) signaling in mouse 3T3-L1 fibroblastic preadipocyte differentiation to mature adipocytes.
Mouse 3T3-L1 preadipocytes were treated with lipoxygenase (LOX) inhibitors, BLT antagonist, and small interfering RNA (siRNA) for BLT1 and BLT2 to block the LTB4-BLT signaling pathway, then the adipocyte differentiation such as lipid accumulation and the increase in triglyceride was evaluated.
Blockade of BLT signaling by treatment with a LOX inhibitor or a BLT antagonist suppressed preadipocyte differentiation into mature adipocytes. In addition, knockdown of BLT1 and BLT2 by siRNAs dramatically inhibited differentiation. These results indicate the LTB4-BLT signaling pathway may positively regulate preadipocyte differentiation and be a rate-limiting system to control adipocyte differentiation.
The LTB4-BLT signaling pathway provides a potent regulatory signal that accelerates the differentiation of mouse 3T3-L1 preadipocytes. Further investigations are necessary to confirm the exact role of LTB4 and BLTs signaling pathways in preadipocyte differentiation.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>23937951</pmid><doi>10.1186/1476-511X-12-122</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 3T3-L1 Cells Adipocytes Adipocytes - drug effects Adipocytes - metabolism Analysis Animals Cell Differentiation - drug effects Cell Differentiation - genetics Cell growth Control systems Dentistry Experiments Health aspects Insulin resistance Insulin Resistance - genetics Leukotriene B4 - genetics Leukotriene B4 - metabolism Leukotrienes Lipids Lipoxygenase - genetics Lipoxygenase - metabolism Lipoxygenase Inhibitors - administration & dosage Mice Obesity Obesity - genetics Obesity - metabolism Obesity - pathology Pharmaceutical industry Proteins Receptors, Leukotriene B4 - genetics Receptors, Leukotriene B4 - metabolism RNA, Small Interfering Rodents Signal Transduction - drug effects Signal Transduction - genetics Statistical analysis Synthesis Triglycerides |
| title | Critical role of leukotriene B4 receptor signaling in mouse 3T3-L1 preadipocyte differentiation |
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