Levonorgestrel releasing intrauterine system (Mirena) versus endometrial ablation (Novasure) in women with heavy menstrual bleeding: a multicentre randomised controlled trial

Heavy menstrual bleeding is an important health problem. Two frequently used therapies are the levonorgestrel intra-uterine system (LNG-IUS) and endometrial ablation. The LNG-IUS can be applied easily by the general practitioner, which saves costs, but has considerable failure rates. As an alternati...

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Bibliographic Details
Published in:BMC women's health 2013-08, Vol.13 (1), p.32-32, Article 32
Main Authors: Herman, Malou C, van den Brink, Marian J, Geomini, Peggy M, van Meurs, Hannah S, Huirne, Judith A, Eising, Heleen P, Timmermans, Anne, Pijnenborg, Johanna M A, Klinkert, Ellen R, Coppus, Sjors F, Nieboer, Theodoor E, Catshoek, Ruby, van der Voet, Lucet F, van Eijndhoven, Hugo W F, Graziosi, Giuseppe C M, Veersema, Sebastiaan, van Kesteren, Paul J, Langenveld, Josje, Smeets, Nicol A C, van Vliet, Huib A A M, van der Steeg, Jan Willem, Lisman-van Leeuwen, Yvonne, Dekker, Janny H, Mol, Ben W, Berger, Marjolein Y, Bongers, Marlies Y
Format: Article
Language:English
Subjects:
Adult
Birth control
Contraceptive Agents, Female - administration & dosage
Endometrial Ablation Techniques - methods
Female
Humans
Hysterectomy
Intrauterine Devices, Medicated - statistics & numerical data
Levonorgestrel - administration & dosage
Medical research
Menstruation
Netherlands
Patient satisfaction
Quality of life
Studies
Study Protocol
Treatment Outcome
Women's Health
Womens health
Young Adult
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Summary:Heavy menstrual bleeding is an important health problem. Two frequently used therapies are the levonorgestrel intra-uterine system (LNG-IUS) and endometrial ablation. The LNG-IUS can be applied easily by the general practitioner, which saves costs, but has considerable failure rates. As an alternative, endometrial ablation is also very effective, but this treatment has to be performed by a gynaecologist. Due to lack of direct comparison of LNG-IUS with endometrial ablation, there is no evidence based preferred advice for the use of one of these treatment possibilities. A multicenter randomised controlled trial, organised in a network infrastructure in the Netherlands in which general practitioners and gynaecologists collaborate. This study, considering both effectiveness and cost effectiveness of LNG-IUS versus endometrial ablation may well improve care for women with heavy menstrual bleeding. Dutch trial register, number NTR2984.
ISSN:1472-6874
1472-6874
DOI:10.1186/1472-6874-13-32