Integrin dynamics produce a delayed stage of long-term potentiation and memory consolidation

Memory consolidation theory posits that newly acquired information passes through a series of stabilization steps before being firmly encoded. We report here that in rat and mouse, hippocampus cell adhesion receptors belonging to the β1-integrin family exhibit dynamic properties in adult synapses an...

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Bibliographic Details
Published in:The Journal of neuroscience 2012-09, Vol.32 (37), p.12854-12861
Main Authors: Babayan, Alex H, Kramár, Enikö A, Barrett, Ruth M, Jafari, Matiar, Häettig, Jakob, Chen, Lulu Y, Rex, Christopher S, Lauterborn, Julie C, Wood, Marcelo A, Gall, Christine M, Lynch, Gary
Format: Article
Language:English
Subjects:
Animals
Hippocampus - physiology
Integrin beta1 - metabolism
Long-Term Potentiation - physiology
Male
Memory - physiology
Mice
Mice, Inbred C57BL
Neural Cell Adhesion Molecules - metabolism
Neuronal Plasticity - physiology
Rats
Rats, Sprague-Dawley
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Summary:Memory consolidation theory posits that newly acquired information passes through a series of stabilization steps before being firmly encoded. We report here that in rat and mouse, hippocampus cell adhesion receptors belonging to the β1-integrin family exhibit dynamic properties in adult synapses and that these contribute importantly to a previously unidentified stage of consolidation. Quantitative dual immunofluorescence microscopy showed that induction of long-term potentiation (LTP) by theta burst stimulation (TBS) activates β1 integrins, and integrin-signaling kinases, at spine synapses in adult hippocampal slices. Neutralizing antisera selective for β1 integrins blocked these effects. TBS-induced integrin activation was brief (
ISSN:0270-6474
1529-2401
1529-2401
DOI:10.1523/jneurosci.2024-12.2012