Exploration of Fluorine Chemistry at the Multidisciplinary Interface of Chemistry and Biology

Over the last three decades, my engagement in “fluorine chemistry” has evolved substantially because of the multidisciplinary nature of the research programs. I began my research career as a synthetic chemist in organometallic chemistry and homogeneous catalysis directed toward organic synthesis. Th...

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Bibliographic Details
Published in:Journal of organic chemistry 2013-07, Vol.78 (13), p.6358-6383
Main Author: Ojima, Iwao
Format: Article
Language:English
Subjects:
Biology
Chemistry
Hydrocarbons, Fluorinated - chemistry
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Summary:Over the last three decades, my engagement in “fluorine chemistry” has evolved substantially because of the multidisciplinary nature of the research programs. I began my research career as a synthetic chemist in organometallic chemistry and homogeneous catalysis directed toward organic synthesis. Then, I was brought into a very unique world of “fluorine chemistry” in the end of 1970s. I started exploring the interface of fluorine chemistry and transition metal homogeneous catalysis first, which was followed by amino acids, peptides, and peptidomimetics for medicinal chemistry. Since then, I have been exploring the interfaces of fluorine chemistry and multidisciplinary fields of research involving medicinal chemistry, chemical biology, cancer biology, and molecular imaging. This perspective intends to cover my fruitful endeavor in the exploration of fluorine chemistry at the multidisciplinary interface of chemistry and biology in a chronological order to show the evolution of my research interest and strategy.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo400301u