Modeling the heterogeneity of multiple sclerosis in animals

Highlights • Multiple animal models are needed to model the heterogeneous features of MS. • Individual EAE models replicate specific features of disease. • Collectively, EAE models link CD4 T, CD8 T, and B cells to disease pathogenesis. • Additional models are needed for primary and secondary progre...

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Bibliographic Details
Published in:Trends in immunology 2013-08, Vol.34 (8), p.410-422
Main Authors: Simmons, Sarah B, Pierson, Emily R, Lee, Sarah Y, Goverman, Joan M
Format: Article
Language:English
Subjects:
Allergy and Immunology
animal models
Animals
Autoimmune diseases
autoimmunity
CD4-positive T-lymphocytes
CD8-positive T-lymphocytes
central nervous system
disease course
encephalitis
Encephalomyelitis, Autoimmune, Experimental - immunology
Encephalomyelitis, Autoimmune, Experimental - pathology
experimental autoimmune encephalomyelitis
Immune system
Medical research
Multiple sclerosis
Multiple Sclerosis - immunology
Multiple Sclerosis - pathology
neuroimmunology
patients
sclerosis
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Summary:Highlights • Multiple animal models are needed to model the heterogeneous features of MS. • Individual EAE models replicate specific features of disease. • Collectively, EAE models link CD4 T, CD8 T, and B cells to disease pathogenesis. • Additional models are needed for primary and secondary progressive MS.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2013.04.006