Mutations in hemG Mediate Resistance to Salicylidene Acylhydrazides, Demonstrating a Novel Link between Protoporphyrinogen Oxidase (HemG) and Chlamydia trachomatis Infectivity

• Published in: Journal of Bacteriology 2013-09, Vol.195 (18), p.4221-4230
• Main Authors: Engström, Patrik, Nguyen, Bidong D, Normark, Johan, Nilsson, Ingela, Bastidas, Robert J, Gylfe, Asa, Elofsson, Mikael, Fields, Kenneth A, Valdivia, Raphael H, Wolf-Watz, Hans, Bergström, Sven
• Format: Article
• Language: English
• Subjects: Amino Acid Sequence; Bacterial Proteins - chemistry; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Bacteriology; Catalytic Domain; Chlamydia trachomatis; Chlamydia trachomatis - drug effects; Chlamydia trachomatis - enzymology; Chlamydia trachomatis - genetics; Chlamydia trachomatis - pathogenicity; Drug Resistance, Bacterial; Enzymes; Gram-negative bacteria; HeLa Cells; Heme - metabolism; Humans; Hydrazines - pharmacology; Iron - metabolism; Iron - pharmacology; Medical treatment; Metabolism; Models, Molecular; Molecular Sequence Data; Mutation; Protoporphyrinogen Oxidase - chemistry; Protoporphyrinogen Oxidase - genetics; Protoporphyrinogen Oxidase - metabolism; Yersinia
• ISSN: 0021-9193; 1098-5530; 1067-8832; 1098-5530
• DOI: 10.1128/JB.00506-13

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