Effects of Acupuncture on 1-Chloro-2,4-dinitrochlorobenzene-Induced Atopic Dermatitis

Though the effects of acupuncture in atopic dermatitis have been proven in clinical studies, its mechanism remains unclear. In this study, we investigate the effectiveness and mechanism of action for acupuncture treatment on the LI11 meridian point for treatment of allergic contact dermatitis. BALB/...

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Published in:Evidence-based complementary and alternative medicine 2013-01, Vol.2013 (2013), p.1-8
Main Authors: Park, Ji-Yeun, Park, Hi-Joon, Choi, You Yeon, Kim, Mi Hye, Kim, Seung-Nam, Yang, Woong Mo
Format: Article
Language:English
Subjects:
1-Chloro-2,4-dinitrobenzene
Acupuncture
Allergies
Atopic dermatitis
Contact dermatitis
Cytokines
Dermatitis
Dinitrobenzene
Eczema
Gene expression
Hyperplasia
Immunoglobulin E
Immunology
Inflammation
Interleukin 4
Interleukin 8
Laboratory animals
mRNA
Neurosciences
NF-κB protein
Pain
Proteins
Skin
Tumor necrosis factor-TNF
Tumor necrosis factor-α
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Summary:Though the effects of acupuncture in atopic dermatitis have been proven in clinical studies, its mechanism remains unclear. In this study, we investigate the effectiveness and mechanism of action for acupuncture treatment on the LI11 meridian point for treatment of allergic contact dermatitis. BALB/c mice received 1-chloro-2,4-dinitrobenzene (DNCB) application to induce skin inflammation. Acupuncture treatment on LI11 significantly inhibited cutaneous hyperplasia, serum IgE levels, and expression of proinflammatory cytokine (IL-4, IL-8, and TNF-α) mRNA and NF-κB, ERK1/2, JNK, and p38 proteins. Acupuncture treatment of local points also inhibited cutaneous hyperplasia and serum IgE levels; however, it was not effective in regulating proinflammatory cytokines and proteins. In addition, LI11 treatment is more effective at reducing serum IgE levels and pro-inflammatory cytokines and proteins than local point treatment. These results suggest that acupuncture treatment is effective in alleviating allergic contact dermatitis by reducing pro-inflammatory cytokines and proteins.Erratum of “Effects of Acupuncture on 1-Chloro-2,4-dinitrochlorobenzene-Induced Atopic Dermatitis”dx.doi.org/10.1155/2013/831539
ISSN:1741-427X
1741-4288
DOI:10.1155/2013/982095