Drosophila H1 Regulates the Genetic Activity of Heterochromatin by Recruitment of Su(var)3-9

Eukaryotic genomes harbor transposable elements and other repetitive sequences that must be silenced. Small RNA interference pathways play a major role in their repression. Here, we reveal another mechanism for silencing these sequences in Drosophila. Depleting the linker histone H1 in vivo leads to...

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Published in:Science (American Association for the Advancement of Science) 2013-04, Vol.340 (6128), p.78-81
Main Authors: Lu, Xingwu, Wontakal, Sandeep N., Kavi, Harsh, Kim, Byung Ju, Guzzardo, Paloma M., Emelyanov, Alexander V., Xu, Na, Hannon, Gregory J., Zavadil, Jiri, Fyodorov, Dmitry V., Skoultchi, Arthur I.
Format: Article
Language:English
Subjects:
Animals
Chromatin
DNA
Drosophila
Drosophila melanogaster - genetics
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Eukaryotes
gene expression
Gene Silencing
Genetic linkage
Genetics
Genomes
germ cells
Heterochromatin
Heterochromatin - metabolism
Histones
Histones - genetics
Histones - metabolism
Insects
Larvae
lysine
methyltransferases
Muscle Proteins - genetics
Nucleosomes
Repetitive Sequences, Nucleic Acid - genetics
Repressor Proteins - metabolism
RNA
RNA Interference
somatic cells
Transcription Factors - genetics
transposons
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cited_by cdi_FETCH-LOGICAL-c509t-498b5fe643e70d2c5a92a7c2ace3445c4437df72c7adcc15edd9646b8ec5fb133
cites cdi_FETCH-LOGICAL-c509t-498b5fe643e70d2c5a92a7c2ace3445c4437df72c7adcc15edd9646b8ec5fb133
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container_issue 6128
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container_title Science (American Association for the Advancement of Science)
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creator Lu, Xingwu
Wontakal, Sandeep N.
Kavi, Harsh
Kim, Byung Ju
Guzzardo, Paloma M.
Emelyanov, Alexander V.
Xu, Na
Hannon, Gregory J.
Zavadil, Jiri
Fyodorov, Dmitry V.
Skoultchi, Arthur I.
description Eukaryotic genomes harbor transposable elements and other repetitive sequences that must be silenced. Small RNA interference pathways play a major role in their repression. Here, we reveal another mechanism for silencing these sequences in Drosophila. Depleting the linker histone H1 in vivo leads to strong activation of these elements. H1-mediated silencing occurs in combination with the heterochromatin-specific histone H3 lysine 9 methyltransferase Su(var) 3-9. H1 physically interacts with Su(var) 3-9 and recruits it to chromatin in vitro, which promotes H3 methylation. We propose that H1 plays a key role in silencing by tethering Su(var) 3-9 to heterochromatin. The tethering function of H1 adds to its established role as a regulator of chromatin compaction and accessibility.
doi_str_mv 10.1126/science.1234654
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identifier ISSN: 0036-8075
ispartof Science (American Association for the Advancement of Science), 2013-04, Vol.340 (6128), p.78-81
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1095-9203
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source American Association for the Advancement of Science; Alma/SFX Local Collection; JSTOR
subjects Animals
Chromatin
DNA
Drosophila
Drosophila melanogaster - genetics
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Eukaryotes
gene expression
Gene Silencing
Genetic linkage
Genetics
Genomes
germ cells
Heterochromatin
Heterochromatin - metabolism
Histones
Histones - genetics
Histones - metabolism
Insects
Larvae
lysine
methyltransferases
Muscle Proteins - genetics
Nucleosomes
Repetitive Sequences, Nucleic Acid - genetics
Repressor Proteins - metabolism
RNA
RNA Interference
somatic cells
Transcription Factors - genetics
transposons
title Drosophila H1 Regulates the Genetic Activity of Heterochromatin by Recruitment of Su(var)3-9
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