Successful Aging Shows Linkage to Chromosomes 6, 7, and 14 in the Amish

Summary Successful aging (SA) is a multidimensional phenotype involving preservation of cognitive ability, physical function, and social engagement throughout life. Multiple components of SA are heritable, supporting a genetic component. The Amish are genetically and socially isolated with homogeneo...

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Bibliographic Details
Published in:Annals of human genetics 2011-07, Vol.75 (4), p.516-528
Main Authors: Edwards, Digna R. Velez, Gilbert, John R., Jiang, Lan, Gallins, Paul J., Caywood, Laura, Creason, Marilyn, Fuzzell, Denise, Knebusch, Clare, Jackson, Charles E., Pericak‐Vance, Margaret A., Haines, Jonathan L., Scott, William K.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging
Amish
chromosome 6
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 7
Cognitive ability
DNA
family‐based study
Female
genealogy
genetic epidemiology
Genetic Linkage
Genome-Wide Association Study
Humans
Linkage analysis
Lod Score
longevity
Longevity - genetics
Male
Pedigree
Pennsylvania
Phenotype
Polymorphism, Single Nucleotide
Population Groups
population isolate
Preservation
Single-nucleotide polymorphism
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Summary:Summary Successful aging (SA) is a multidimensional phenotype involving preservation of cognitive ability, physical function, and social engagement throughout life. Multiple components of SA are heritable, supporting a genetic component. The Amish are genetically and socially isolated with homogeneous lifestyles, making them a suitable population for studying the genetics of SA. DNA and measures of SA were collected on 214 cognitively intact Amish individuals over age 80. Individuals were grouped into a 13‐generation pedigree using the Anabaptist Genealogy Database. A linkage screen of 5944 single nucleotide polymorphisms (SNPs) was performed using 12 informative subpedigrees with an affected‐only 2‐point and multipoint linkage analysis. Eleven SNPs produced 2‐point LOD scores >2, suggestive of linkage. Multipoint linkage analyses, allowing for heterogeneity, detected significant LOD scores on chromosomes 6 (HLOD = 4.50), 7 (LOD*= 3.11), and 14 (HLOD = 4.17), suggesting multiple new loci underlying SA.
ISSN:0003-4800
1469-1809
DOI:10.1111/j.1469-1809.2011.00658.x