Decreased Birth Weight in Psychosis: Influence of Prenatal Exposure to Serologically Determined Influenza and Hypoxia

Decreased birth weight (BW) is associated with later psychosis, but the sources of decreased BW for those at risk for psychosis remain unclear. To determine whether fetal exposure to influenza and/or hypoxia accounts for BW decreases among psychotic cases and controls. Subjects were 111 cases diagno...

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Bibliographic Details
Published in:Schizophrenia bulletin 2013-09, Vol.39 (5), p.1037-1044
Main Authors: FINEBERG, Anna M, ELLMAN, Lauren M, BUKA, Stephen, YOLKEN, Robert, CANNON, Tyrone D
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Affective Disorders, Psychotic - blood
Affective Disorders, Psychotic - etiology
Biological and medical sciences
Birth Weight
Female
Fetal Blood - immunology
Fetal Blood - metabolism
Fetal Hypoxia - blood
Fetal Hypoxia - complications
Gestational Age
Human viral diseases
Humans
Infant, Low Birth Weight
Infant, Newborn
Infectious diseases
Influenza, Human - blood
Influenza, Human - complications
Male
Medical sciences
Philadelphia
Pregnancy
Prenatal Exposure Delayed Effects - blood
Prenatal Exposure Delayed Effects - etiology
Prospective Studies
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Regular
Retrospective Studies
Risk Factors
Schizophrenia
Schizophrenia - blood
Schizophrenia - etiology
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
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Summary:Decreased birth weight (BW) is associated with later psychosis, but the sources of decreased BW for those at risk for psychosis remain unclear. To determine whether fetal exposure to influenza and/or hypoxia accounts for BW decreases among psychotic cases and controls. Subjects were 111 cases diagnosed with schizophrenia or affective psychosis and 333 matched controls from the Collaborative Perinatal Project. Psychiatric diagnoses were ascertained from medical records. Influenza and hypoxia were determined from maternal and cord sera collected at birth. Cases exposed to severe fetal hypoxia or influenza had significantly lower BW compared with unexposed cases and controls, regardless of exposure status. No significant differences in BW were observed among controls based on exposure status. Decreased BW appears to be a risk factor for psychosis only in the presence of other teratogens. Liability to psychosis likely renders fetuses vulnerable to decreased fetal growth in response to hypoxia and influenza.
ISSN:0586-7614
1745-1701
DOI:10.1093/schbul/sbs084