Network model of a protein globule

Phase transition of a protein globule is considered in the frameworks of (i) the generalized mean-field theory for the order parameter, characterizing the extent of the deviation of a protein three-dimensional structure from its native state and (ii) the network model that treats a protein globule a...

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Bibliographic Details
Published in:Journal of biological physics 2013-09, Vol.39 (4), p.673-685
Main Authors: Meilikhov, E. Z., Farzetdinova, R. M.
Format: Article
Language:English
Subjects:
Amino acids
Biochemistry
Biological and Medical Physics
Biophysics
Complex Fluids and Microfluidics
Complex Systems
Models, Molecular
Neurosciences
Original Paper
Phase transitions
Physics
Physics and Astronomy
Polypeptides
Protein Stability
Proteins
Proteins - chemistry
Soft and Granular Matter
Temperature
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Summary:Phase transition of a protein globule is considered in the frameworks of (i) the generalized mean-field theory for the order parameter, characterizing the extent of the deviation of a protein three-dimensional structure from its native state and (ii) the network model that treats a protein globule as a small-world network with a significant percent of long-range links between amino acid residues. Temperature dependencies of the introduced order parameter are defined and phase-transition temperatures are found on the basis of the function defining the distribution of links’ numbers for protein residues. An important role of long-range links, promoting considerable rise of thermal protein stability, is demonstrated by the example of a correlation between protein melting temperature and a fraction of disulfide bonds.
ISSN:0092-0606
1573-0689
DOI:10.1007/s10867-013-9326-8