Generation of erythroid cells from fibroblasts and cancer cells in vitro and in vivo

Highlights ►CoCl2 can induce formation of stem-like cells (PGCs or PGCCs) ► CoCl2 activates the expression of hemoglobins that may lead to formation of erythroid cells.► Fibroblasts and cancer cells may obtain O2 in response to hypoxia without angiogenesis. ► CoCl2 may be a useful agent in helping t...

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Bibliographic Details
Published in:Cancer letters 2013-06, Vol.333 (2), p.205-212
Main Authors: Zhang, Shiwu, Mercado-Uribe, Imelda, Liu, Jinsong
Format: Article
Language:English
Subjects:
Animals
Biomarkers - analysis
c-Myc
Cell Differentiation - genetics
Cell Hypoxia
Cell Line, Tumor
Cobalt - pharmacology
Cobalt chloride
Erythroid cells
Erythroid Cells - cytology
Erythroid Cells - drug effects
Erythroid Precursor Cells - cytology
Female
Fibroblasts - cytology
Fibroblasts - drug effects
Fibroblasts - physiology
Genes, myc
Hematology, Oncology and Palliative Medicine
Hemoglobins - biosynthesis
Humans
Hypoxia
Mice
Mice, SCID
Ovarian Neoplasms - pathology
Ovary - cytology
Solid tumor cells
Spheroids, Cellular - drug effects
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Summary:Highlights ►CoCl2 can induce formation of stem-like cells (PGCs or PGCCs) ► CoCl2 activates the expression of hemoglobins that may lead to formation of erythroid cells.► Fibroblasts and cancer cells may obtain O2 in response to hypoxia without angiogenesis. ► CoCl2 may be a useful agent in helping to generate unlimited red bllod cells in vitro.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.01.037