A threshold concentration of anti-merozoite antibodies is required for protection from clinical episodes of malaria

Highlights • We hypothesized that a threshold antibody concentration is required for protection. • Thresholds were derived using statistical methods in a high transmission setting. • Thresholds were applied to a low transmission setting. • Most children had antibodies below the threshold in the low...

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Bibliographic Details
Published in:Vaccine 2013-08, Vol.31 (37), p.3936-3942
Main Authors: Murungi, Linda M, Kamuyu, Gathoni, Lowe, Brett, Bejon, Philip, Theisen, Michael, Kinyanjui, Samson M, Marsh, Kevin, Osier, Faith H.A
Format: Article
Language:English
Subjects:
Allergy and Immunology
Anti-merozoite antibodies
antibodies
Antibodies, Protozoan - blood
Antibodies, Protozoan - immunology
Antigens
Antigens, Protozoan - genetics
Antigens, Protozoan - immunology
Applied microbiology
Biological and medical sciences
Child
Child, Preschool
children
Clinical malaria
coasts
Cohort Studies
Fundamental and applied biological sciences. Psychology
Human protozoal diseases
Humans
Immuno-epidemiology
Infant
Infant, Newborn
Infectious diseases
Kenya
Malaria
Malaria - immunology
Malaria - parasitology
Malaria - prevention & control
Malaria - transmission
Medical sciences
merozoites
Merozoites - immunology
Microbiology
Parasites
Parasitic diseases
Plasmodium falciparum
Plasmodium falciparum - immunology
Protection
Protective threshold antibody concentrations
Protozoal diseases
risk
Risk Factors
Risk reduction
statistical analysis
Statistical methods
Studies
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vector-borne diseases
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Summary:Highlights • We hypothesized that a threshold antibody concentration is required for protection. • Thresholds were derived using statistical methods in a high transmission setting. • Thresholds were applied to a low transmission setting. • Most children had antibodies below the threshold in the low transmission setting.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.06.042